AI Article Synopsis
- The aging process leads to a decline in stem cell function, causing issues with tissue maintenance and repair.
- Age-related DNA damage in both stem cells and their surrounding cells is a key factor in this decline, potentially leading to stem cell dysfunction and increased cancer risk.
- The review highlights insights into how different types of DNA damage affect stem cell functionality, and discusses both internal and external factors that impact these changes, along with recent research on systemic responses to DNA damage.
Article Abstract
Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214082 | PMC |
| http://dx.doi.org/10.1038/ncb2928 | DOI Listing |
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