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B12-Dependent Radical SAM Enzymes Catalyze C-Fluoromethylation via a CHF-Cobalamin Intermediate.
Angew Chem Int Ed Engl
January 2025
Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.
Fluorine and fluorine-containing functional groups play important roles in drugs and agrochemicals. Recently, SAM-dependent methyltransferases and several SAM analogues have been reported for fluoromethyl transfer through a nucleophilic mechanism. However, fluoromethylation of unactivated carbon centers is very challenging, and their substitution usually involves a radical mechanism.
View Article and Find Full Text PDFDistinguishing deception from its confounds by improving the validity of fMRI-based neural prediction.
Proc Natl Acad Sci U S A
December 2024
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720.
Deception is a universal human behavior. Yet longstanding skepticism about the validity of measures used to characterize the biological mechanisms underlying deceptive behavior has relegated such studies to the scientific periphery. Here, we address these fundamental questions by applying machine learning methods and functional magnetic resonance imaging (fMRI) to signaling games capturing motivated deception in human participants.
View Article and Find Full Text PDFBlood Pressure Control for Patients with Middle Cerebral Artery Severe Stenosis or Occlusion.
Clin Interv Aging
November 2024
Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People's Republic of China.
Background: Chronic hypertension is an independent risk factor for ischemic stroke and worsens prognosis. However, the level of blood pressure control in hypertensive patients with severe intracranial stenosis is controversial.
Purpose: To investigate the effect of different levels of blood pressure on cerebral perfusion in patients with middle cerebral artery severe stenosis or occlusion.
Adolescent Blood Pressure and Early Age Stroke.
NEJM Evid
December 2024
The Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Ramat Gan, Israel.
Background: Underdiagnosis of relevant risk factors has contributed to the increasing stroke incidence in young adults. Blood pressure cut-off values for adolescents are neither sex specific nor based on cardiovascular outcomes.
Methods: This nationwide, population-based, retrospective cohort study included all Israeli adolescents 16-19 years of age who were medically evaluated before compulsory military service from 1985 to 2013, including routine blood pressure measurements.
An Unusual Hunting Accident: A Case Report.
Cureus
August 2024
Institute of Forensic Medicine, Faculty of Medicine, University of Debrecen, Debrecen, HUN.
In Hungary, possessing certain weapons (e.g. firearms, bows, air pistols, and air guns mainly over 7.
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