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Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.
JAMA Ophthalmol
January 2025
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Importance: Primary open-angle glaucoma (POAG) polygenic risk scores (PRSs) continue to be evaluated in primarily European-ancestry populations despite higher prevalence and worse outcomes in African-ancestry populations.
Objective: To evaluate how established POAG PRSs perform in African-ancestry samples from the Genetics in Glaucoma Patients of African Descent (GIGA), Genetics of Glaucoma in Individuals of African Descent (GGLAD), and Million Veteran Program (MVP) datasets and compare these with European-ancestry samples.
Design, Setting, And Participants: This was a multicenter, cross-sectional study of POAG cases and controls from Tanzania, South Africa, Nigeria, Ghana, and the US.
Brain plasticity, language anomalies, genetic risk and the patient with schizophrenia: Trajectory of change over a lifetime. A commentary.
Psychiatry Res
February 2023
Department of Psychiatry, Cambridge Health Alliance and Harvard Medical School, Cambridge, Massachusetts, United States. Electronic address:
Research on schizophrenia has been pursued for over a century. While the ability to view the brain and also the entire human genome advanced dramatically during this time and particularly in recent years, it is still unclear whether these advances helped to understand the nature of schizophrenia. What appears, however, to be the case is that early detection and treatment of people who are at high risk for developing schizophrenia due to various clinical signs, lead to better outcomes and recovery in many cases.
View Article and Find Full Text PDFThe mental health consequences on children of the war in Ukraine: A commentary.
Psychiatry Res
November 2022
Department of Psychiatry, Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, United States.
The news from Ukraine is currently full of heart-wrenching stories accompanied by graphic images of civilian casualties and massacres that are telecast world-wide on a daily basis. It is hard to fathom the magnitude of the devastation and disruption to regular lives and everyday routines that war brings with it, the witnessing of countless deaths, the associated trauma of living in perpetual fear, and the daily experience of many families and orphans who are crowded into basement bomb shelters now for months on end. These issues make us contemplate the mental health consequences, among other lasting effects, of this costly war in Ukraine, and wars in other countries not so widely featured in Western news.
View Article and Find Full Text PDFCommentary on whether progressive brain change underlies the pathology of schizophrenia: Should this even be debated?
Schizophr Res
June 2022
Attending Psychiatrist and Director of Faculty Affairs, Department of Psychiatry, Cambridge Health Alliance, Professor of Psychiatry, Harvard Medical School, Cambridge, MA, United States of America. Electronic address:
Constructive principles for gene editing oversight.
Nat Biotechnol
January 2022
New England Biolabs, Ipswich, MA, USA.
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