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Boosting the catalytic efficiency of UGT51 for efficient production of rare ginsenoside Rh2.
Folia Microbiol (Praha)
January 2025
Biofuels Institute, School of Emergency Management, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, China.
Ginsenoside Rh2(S) is well-known for its therapeutic potential against diverse conditions, including some cancers, inflammation, and diabetes. The enzymatic activity of uridine diphosphate glycosyltransferase 51 (UGT51) from Saccharomyces cerevisiae plays a pivotal role in the glycosylation process between UDP-glucose (donor) and protopanaxadiol (acceptor), to form ginsenoside Rh2. However, the catalytic efficiency of the UGT51 has remained a challenging task.
View Article and Find Full Text PDFComplex Health Needs in Hurricane-Affected Youth and Their Families: Barriers, Vulnerabilities, and Mental Health Outcomes.
Res Child Adolesc Psychopathol
January 2025
Department of Psychology, University of South Dakota, 414 East Clark Street, Vermillion, SD, USA.
Youth with complex health needs (CHNs; e.g., requiring daily assistance or equipment for care) and their parents face heightened vulnerabilities during natural disasters, potentially leading to poorer mental health outcomes compared to those without CHNs.
View Article and Find Full Text PDFIsolation and characterization of haploid heterothallic beer yeasts.
Appl Microbiol Biotechnol
January 2025
Department of Microbiology and Biochemistry, Hochschule Geisenheim University, Von-Lade-Straße 1, 65366, Geisenheim, Germany.
Improving ale or lager yeasts by conventional breeding is a non-trivial task. Domestication of lager yeasts, which are hybrids between Saccharomyces cerevisiae and Saccharomyces eubayanus, has led to evolved strains with severely reduced or abolished sexual reproduction capabilities, due to, e.g.
View Article and Find Full Text PDFGenetically Predicted Leucine Level Mediates Association Between CD4/CD8br T Lymphocytes and Insomnia.
Cell Mol Neurobiol
January 2025
Department of Anesthesiology, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, 410008, China.
Immune and metabolic factors play an important role in the onset and development of insomnia. This study aimed to investigate the causal relationship between insomnia and immune cells and metabolites. Data for 731 immune cell phenotypes, 1400 metabolites, and insomnia in this study were obtained from the GWAS open-access database.
View Article and Find Full Text PDFConstructive feedback on the efficacy of tip-flexible suction access sheath in ureteroscopic lithotripsy for unilateral upper urinary tract calculi.
World J Urol
January 2025
Department of Urology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
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