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| http://dx.doi.org/10.4103/0973-029X.125225 | DOI Listing |
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High-grade transformation in adenoid cystic carcinoma: Can it be diagnosed on cytology? A cytohistological correlation.
Cytojournal
March 2024
Department of Pathology, AIIMS, Raebareli, Uttar Pradesh, India.
Adenoid cystic carcinomas (ADCC) are distinctive salivary gland neoplasms with characteristic histomorphology. The diagnosis of dedifferentiation/high-grade transformation (HGT) indicates poor prognosis and is most often made on histopathology. We present a case of ADCC arising from a minor salivary gland tumor exhibiting HGT, reaching up to the submandibular gland and having lymph node metastases, suspected on fine-needle aspiration cytology.
View Article and Find Full Text PDFVulvar Adenoid Cystic Carcinoma with Squamous Cell Carcinoma Component.
Kurume Med J
May 2024
Department of Plastic and Reconstructive Surgery, Maxillofacial Surgery, Kurume University School of Medicine.
Adenoid cystic carcinoma (ACC) is a major histological type of salivary gland cancer but an uncommon form of vulvar cancer. Salivary gland ACC occasionally dedifferentiates into high-grade carcinoma, resulting in poor prognoses. The dedifferentiated component is usually a poorly differentiated cribriform or solid carcinoma, whereas squamous cell carcinoma (SCC) is exceptional.
View Article and Find Full Text PDFHigh-grade transformation of head and neck adenoid cystic carcinoma demonstrates distinctive clinicopathological features and an unfavorable prognosis: a matched case-control study of the largest series in China.
Clin Transl Oncol
June 2024
Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, 1, DongJiaoMinXiang Street, DongCheng District, Beijing, 100730, People's Republic of China.
Article Synopsis
- This study examines high-grade transformation (HGT) in adenoid cystic carcinoma (ACC), revealing its aggressive behavior and the serious clinical consequences for patients.
- Researchers compared 23 HGT patients to non-HGT patients, finding HGT primarily in sinonasal and lacrimal glands, with a worrying increase in lymph node metastasis, perineural invasion, and tumor growth.
- The findings indicate that patients with HGT face higher rates of recurrence and distant metastasis, suggesting they should be classified as Grade 4 due to their significantly worse survival rates compared to non-HGT cases.
Lacrimal Gland Adenoid Cystic Carcinoma with High Grade Transformation: A Case Report and Current Concepts in Multi Modality Management.
Indian J Otolaryngol Head Neck Surg
October 2022
Department of Surgical Oncology, Zydus Cancer Centre, Zydus Hospital, Ahmedabad, Gujarat 380054 India.
Lacrimal gland adenoid cystic carcinoma (AdCC) is associated with an aggressive clinical course and grave prognosis. A high grade transformation within adenoid cystic carcinoma of lacrimal gland is a rare condition which is even more locally aggressive with frequent neck and distant metastasis. We present a case of left lacrimal gland adenoid cystic carcinoma with high grade transformation to adenocarcinoma NOS type presenting with orbital pain and proptosis.
View Article and Find Full Text PDFHigh-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.
Adv Anat Pathol
May 2021
International Head and Neck Scientific Group, Padua, Italy.
Article Synopsis
- High-grade transformation (HGT) and dedifferentiation occur in various salivary gland carcinomas, including acinic cell and adenoid cystic carcinoma, leading to a mix of low-grade and high-grade tumor features.
- The high-grade component is characterized by poorly differentiated cells with distinct microscopic changes, higher cell proliferation rates, and aggressive behavior, resulting in poorer patient outcomes.
- The exact molecular mechanisms behind HGT are not fully understood, but changes like p53 inactivation and increased HER2 levels have been observed; hence, thorough examinations of salivary gland tumors are critical to identify high-grade areas for better treatment planning.
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