AI Article Synopsis
- * The review discusses the origins of microglia, how they invade the developing embryonic central nervous system, and their interactions with the surrounding environment during this process.
- * It highlights the importance of microglia in developing neural networks, including their contributions to neurogenesis, blood vessel formation (angiogenesis), and the elimination of unnecessary cells during growth.
Article Abstract
Microglia cells are the macrophages of the central nervous system with a crucial function in the homeostasis of the adult brain. However, recent studies showed that microglial cells may also have important functions during early embryonic central nervous system development. In this review we summarize recent works on the extra embryonic origin of microglia, their progenitor niche, the pattern of their invasion of the embryonic central nervous system and on interactions between embryonic microglia and their local environment during invasion. We describe microglial functions during development of embryonic neuronal networks, including their roles in neurogenesis, in angiogenesis and developmental cell death. These recent discoveries open a new field of research on the functions of neural-microglial interactions during the development of the embryonic central nervous system.
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| http://dx.doi.org/10.1051/medsci/20143002011 | DOI Listing |
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