AI Article Synopsis
- * The NBD probe showed a significant increase in fluorescence (110-fold) when it reacted with a large amount of tetrabutyl ammonium fluoride (TBAF), indicating a strong selective response to fluoride ions within 80 minutes.
- * This off-on fluorescence feature allows the probe to be used for real-time imaging of fluoride ions inside living cells.
Article Abstract
The design, synthesis and fluoride sensing ability of a 7-nitro-2,1,3-benzoxadiazole (NBD) based chemodosimeter is reported. Theoretical calculations were used to design a more applicable off-on response, by choosing NBD as the accurate fluorophore. Reaction of the NBD-probe with 300 equivalents of tetrabutyl ammonium fluoride (TBAF) exhibited a response time of 80 minutes and the reaction was selective to F(-) and sensing of the ion was marked by a 110-fold enhancement of green fluorescence. The off-on fluorescence characteristics of the probe enabled its application in live-cell imaging of intracellular F(-) ions.
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| http://dx.doi.org/10.1039/c3ob41886c | DOI Listing |
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