AI Article Synopsis
- - This study examines how mefepronic acid (MA) affects the liver functions and reproduction in postpartum dairy cows by comparing two groups of 60 Friesian cows, one treated with MA and a control group.
- - The treatment group (Group A) showed increased levels of HDL, glucose, and cholesterol, as well as higher PPAR-α positive cells in their liver, suggesting better metabolic health.
- - Improvements in reproductive parameters were also noted in Group A, highlighting MA's potential benefits for both hepatic metabolism and reproductive outcomes in dairy cows after calving.
Article Abstract
This study investigates the effects of mefepronic acid (MA), a PPAR-α agonist, on hepatic metabolic functions and reproduction of postpartum dairy cows. Sixty Friesian cows were divided into Group A (administered 5g of MA IM, within 24 hrs after calving, on the 3(rd) and 5(th) day postpartum) and Group B (control). All the cows were blood sampled within 24 hrs of calving (Day 0), on Day 3, 5, 10, 15, 30, and 40 postpartum. On plasma, metabolic and biochemical parameters were determined. Liver biopsies were performed on Day 0, 15 and 30 for the evaluation of hepatic lipid and glycogen content. Reproductive parameters were also evaluated. In Group A, blood HDL, glucose and cholesterol increased till the end of the study, in accordance with the histological results. PPAR-α immunopositive cells increased in liver slices of Group A, too. Reproductive parameters improved in Group A. This study highlights the beneficial effects of mefepronic acid on the hepatic metabolism and reproductive parameters of post-partum dairy cows.
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| http://dx.doi.org/10.2174/1871530314666140223184913 | DOI Listing |
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