AI Article Synopsis
- The study aimed to analyze clinical characteristics and antibiotic resistance patterns of neonates with E. coli bacteremia, including genetic relatedness and virulence traits of the isolates.
- A total of 24 newborns were examined, revealing high rates of antibiotic resistance, particularly against ampicillin (75%) and other common treatments, with certain genetic types (ST95 and ST131) being more prevalent.
- The presence of virulence factors, like the K1 capsule, was noted in half of the isolates, with implications for increased invasiveness in very young infants; hence, ongoing monitoring for resistance and virulence in E. coli is essential.
Article Abstract
Objectives: The objective of this study was to describe the clinical characteristics of neonates with Escherichia coli bacteremia and the antibiotic resistance pattern of the bacterial isolates. We assessed the isolates' genetic relatedness and virulence phenotypic characteristics in vitro.
Study Design: A total of 24 neonates with E. coli bacteremia were identified prospectively in a tertiary-care hospital. Clinical and antibiotic resistance data were investigated. The E. coli isolates were analyzed by multilocus sequence typing (MLST); the presence of the K1 capsule and their ability to invade intestinal epithelial cells were also assessed.
Results: Most newborns were very low birth weight infants. Overall, 75% of the isolates were ampicillin resistant and 17% were gentamicin and tobramycin nonsusceptible. MLST determined sequence types 95 and 131 (ST95 and ST131) predominated, with ST131 becoming significantly more prevalent recently. The K1 capsule was present in 50% of the isolates. ST131 isolates and those producing bacteremia in newborns younger than 7 days showed a highly invasive phenotype.
Conclusion: Resistance to antibiotics currently used empirically to treat newborns is present in bacteremia-producing E. coli. Clonal spread among newborns of multidrug-resistant E. coli is possible; therefore, continued surveillance is needed. Identification of additional virulence factors associated with increased invasion in neonatal E. coli strains is important and further studies are warranted.
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| http://dx.doi.org/10.1055/s-0034-1370341 | DOI Listing |
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