Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271160 | PMC |
| http://dx.doi.org/10.3390/molecules19022469 | DOI Listing |
Publication Analysis
Top Keywords
novel lycorine
8
lycorine derivatives
8
anticancer activities
8
cancer cell
8
cell lines
8
derivatives anticancer
4
anticancer agents
4
agents synthesis
4
synthesis vitro
4
vitro biological
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!