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Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness.
Front Immunol
December 2024
Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States.
Introduction: Despite continued improvement in post-sepsis survival, long term morbidity and mortality remain high. Chronic critical illness (CCI), defined as persistent inflammation and organ injury requiring prolonged intensive care, is a harbinger of poor long-term outcomes in sepsis survivors. Current dogma states that sepsis survivors are immunosuppressed, particularly in CCI.
View Article and Find Full Text PDFThibang Diphatlha: a sequential multiple assignment randomized trial designed to increase timely adoption of cervical cancer treatment in Botswana.
Implement Sci Commun
November 2024
Penn Center for Cancer Care Innovation (PC3I), Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
Background: Delays and missed opportunities for timely treatment contribute significantly to stark inequities in cervical cancer mortality in low- and middle-income countries (LMICs) compared to high-income countries. The vast majority (approximately 90%) of new cases and deaths occur in LMICs, particularly those with high rates of HIV such as Botswana. To date, most of the implementation and cancer control research in Botswana and other LMICs has focused on cancer prevention and screening, with limited focus on cancer treatment.
View Article and Find Full Text PDFNF1 expression profiling in IDH-wildtype glioblastoma: genomic associations and survival outcomes.
Acta Neuropathol Commun
October 2024
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: NF1 inactivation is associated with sensitivity to MEK inhibitor targeted therapy in low-grade and some high-grade gliomas. NF1 loss may also be a harbinger of exploitable vulnerabilities in IDH-wildtype glioblastoma (GBM). Accurate and consistent detection of NF1 loss, however, is fraught given the large gene size, challenges with complete coverage and variant calling upon sequencing, and mechanisms of mRNA and protein regulation that result in early degradation in the absence of genomic alterations.
View Article and Find Full Text PDFBrief Resolved Unexplained Event: Evidence-Based and Family-Centered Management.
Pediatr Rev
October 2024
Division of Hospital Medicine, Department of Pediatrics, Seattle Children's Hospital, University of Washington, and Seattle Children's Research Institute, Center for Clinical and Translational Research, Seattle, WA.
Article Synopsis
- Brief resolved unexplained events (BRUEs) are common in infants under 1 year, characterized by being asymptomatic with no clear diagnosis; less than 5% are linked to serious conditions.
- Despite the low risk of serious issues, about 63% of BRUE cases lead to hospitalization, and up to 82% result in diagnostic testing, often leading to false positives.
- Effective management of BRUE requires balancing reassurance for anxious parents while explaining risks versus benefits of tests, with a family-centered approach to decision-making that respects caregivers' values.
Molecular, Socioeconomic, and Clinical Factors Affecting Racial and Ethnic Disparities in Colorectal Cancer Survival.
JAMA Oncol
November 2024
Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston.
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