Objective: The present study discusses paclitaxel (PTX)-loaded mannosylated-DSPE (Distearoyl-phosphatidyl-ethanolamine) solid lipid nanoparticles (M-SLNs) using mannose as a lectin receptor ligand conjugate for lung cancer targeting and to increase the anticancer activity of PTX against A549 lung's epithelial cancer cells.
Materials And Methods: The PTX-SLNs were prepared by solvent injection method and mannose was conjugated to the free amine group of stearylamine. The M-SLNs obtained were characterized for their particle size, polydispersity index, zeta potential and morphology by transmission electron microscope.
Results: The M-SLNs were spherical in shape with 254 ± 2.3 nm average size, positive zeta potential (3.27 mV), 79.4 ± 1.6 drug entrapment efficiency and showed the lower extent of drug release 40% over 48 h in vitro. Cytotoxicity study on A549 cell lines and biodistrubtion study of drug revealed that M-SLNs deliver a higher concentration of PTX as compared to PTX-SLNs in an alveolar cell site.
Discussion And Conclusion: These results suggested that mannosylated M-SLNs are safe and potential vector for lung cancer targeting.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/03639045.2014.891130 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Water pollution caused by ash from grassland fires alters the molecular, biochemical, and morphological biomarkers of non-biting midge larvae.
J Hazard Mater
December 2024
Post-graduation program in Ecology and Biodiversity Conservation, Federal University of Mato Grosso (UFMT), Mato Grosso, MT 78060-900, Brazil; Post-graduation program in Ecology. Department of Ecology and Zoology, Laboratory of Freshwater Biodiversity, Federal University of Santa Catarina (UFSC), Florianópolis, SC 88040-900, Brazil.
The frequency and intensity of wildfires have been increasing in many parts of the world, which may result in biodiversity loss. Wildfires can devastate plant communities, generating toxic ash that pollutes watercourses through runoff. However, our understanding of the effects of ash exposure on aquatic biodiversity is still limited.
View Article and Find Full Text PDFFoaming of semi-solid gel - An emerging concept in the food lipid sector.
Food Chem
December 2024
Amity Institute of Biotechnology, Amity University, Jaipur, Rajasthan, India. Electronic address:
The research on the foaming of semi-solid gel (oleogel) has recently attracted the attention of food scientists owing to its functional characteristics that make it a potential alternative to saturated fat and trans-fat used in food products. The oleofoams are prepared by heating the vegetable oil with an oleogelator followed by cooling to form a semi-solid gel and then incorporating air in the semi-solid gel to form an air-in-oil system having higher stability to deformation. Oleofoams provide new opportunities for the development of novel aerated food products free of saturated and trans fatty acids to meet the growing demand of consumers for healthy foods.
View Article and Find Full Text PDFInsight into the effect of GSH curing treatment on the flavor formation of chicken meat.
Food Chem
December 2024
School of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Glutathione (GSH) is an important precursor of meat flavor. This study aimed to evaluate the effect of GSH-curing on the flavor of cooked chicken. GSH-cured chicken with different concentrations and uncured chicken (blank) were roasted separately and comprehensively analyzed in terms of flavors, odor-active compounds, free amino acids, and fatty acids profile.
View Article and Find Full Text PDFEngineered DR/NIR dual-emission carbonized polymer dots for simultaneous tracking of lipid droplets and lysosomes.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Key Laboratory of Chemo/Biosensing, Laboratory of Optical Probes and Bioelectrocatalysis (LOPAB), Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, PR China. Electronic address:
Developing near-infrared fluorescent probes for simultaneous tracking of lipid droplets (LDs) and lysosomes is highly desirable for studying cell metabolism. In this work, deep-red/near-infrared dual-emission carbonized polymer dots (DN-CPDs) were prepared for ratiometric monitoring of the intracellular polarity. Detailed structural analysis revealed that the deep-red emission and near-infrared peak of DN-CPDs originate from the molecular state and surface state, respectively.
View Article and Find Full Text PDFInnovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy.
Nanomedicine (Lond)
December 2024
Department of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, India.
Millions of people worldwide suffer from cancer, facing challenges such as treatments affecting healthy cells, suboptimal responses, adverse effects, recurrence risk, drug resistance, and nonspecific targeting. Chemoresistance leads to fatalities, but phytoactives show promise in cancer management despite limitations such as high metabolism, poor absorption, and high dosage requirements. Challenges in the large-scale isolation of phytoactive compounds, solubility, bioavailability, and targeting limit their development.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!