Purpose: To report the surgical outcome of superior oblique tendon split lengthening for management of patients with severe type of congenital Brown syndrome. Brown syndrome is characterized by hypotropia in primary position and limitation of elevation in adduction more than -4.

Materials And Methods: Fourteen consecutive patients with severe congenital Brown syndrome underwent superior oblique split lengthening surgery (10 mm). The amount of hypotropia in primary gaze and the degree of elevation in adduction were compared before and after the surgery. Any surgical complications were also recorded.

Results: Surgery was performed on 15 eyes in 11 female and 3 male subjects. Mean postoperative follow-up time was 12.93 ± 1.79 months (ranging from 10 to 16 months). Average hypotropia in primary gaze improved from 16.2 ± 5.5 prism diopters (range: 10-25 prism diopters) preoperatively to 5.9 ± 4.0 prism diopters (range: 0-18 prism diopters) postoperatively recorded at final follow-up examination (p < 0.001). The limitation in adduction improved from -7.2 ± 4.5 (range: -6 to -8) preoperatively to -1.8 ± 1.3 (range: zero to -5) postoperatively (p < 0.001). No surgical complications were noted.

Conclusion: Superior oblique split lengthening has a significant effect on reducing primary gaze hypotropia and improving elevation in adduction. This technique should be considered for the treatment of patients with severe congenital Brown syndrome.

Download full-text PDF

Source
http://dx.doi.org/10.3109/09273972.2013.877943DOI Listing

Publication Analysis

Top Keywords

brown syndrome
16
prism diopters
16
superior oblique
12
hypotropia primary
12
oblique split
8
split lengthening
8
patients severe
8
congenital brown
8
elevation adduction
8
primary gaze
8

Similar Publications

Background: Current research on hirsutism reveals disparities and knowledge deficiencies, particularly in underrepresented cohorts. Our objective is to scrutinize demographic variances in hirsutism rates.

Patients And Methods: Using the All of Us database, we conducted a cross-sectional analysis encompassing 172,401 women.

View Article and Find Full Text PDF

Background: Strabismus is a potential cause of ocular morbidity.

Objective: The aim of this study was to determine the frequency, types of manifest strabismus and co-morbidities among patients attending a referral paediatric ophthalmology and strabismus clinic in Calabar, Nigeria.

Methods: A retrospective review of case-notes of patients attending the paediatric ophthalmology and strabismus clinic from January 1, 2017 to December 31, 2019 was done.

View Article and Find Full Text PDF

Objective: Whereas a few studies have evaluated vestibular involvement in Fabry disease (FD), the relationship between vestibular/oculomotor abnormalities and disease-specific biomarkers remain unclear. Therefore, we seek to evaluate these quantitatively and analyze their relationship with disease phenotype and biomarkers in FD.

Methods: This cohort study enrolled 37 Chinese FD patients registered in our center.

View Article and Find Full Text PDF

Background/objectives: Strabismus is the most common ocular disorder of childhood. Three rare, recurrent genetic duplications have been associated with both esotropia and exotropia, but the mechanisms by which they contribute to strabismus are unknown. This work aims to investigate the mechanisms of the smallest of the three, a 23 kb duplication on chromosome 4 (hg38|4:25,554,985-25,578,843).

View Article and Find Full Text PDF

Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia.

Biomedicines

December 2024

Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.

Preeclampsia (preE) is a severe multisystem hypertensive syndrome of pregnancy associated with ischemia/hypoxia, angiogenic imbalance, apolipoprotein E (ApoE)-mediated dyslipidemia, placental insufficiency, and inflammation at the maternal-fetal interface. Our recent data further suggest that preE is associated with impaired autophagy, vascular dysfunction, and proteinopathy/tauopathy disorder, similar to neurodegenerative diseases such as Alzheimer's disease (AD), including the presence of the cis stereo-isoform of phosphorylated tau (cis P-tau), amyloid-β, and transthyretin in the placenta and circulation. This review provides an overview of the factors that may lead to the induction and accumulation of cis P-tau-like proteins by focusing on the inactivation of peptidyl-prolyl cis-trans isomerase (Pin1) that catalyzes the cis to trans isomerization of P-tau.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!