Purpose: To report the surgical outcome of superior oblique tendon split lengthening for management of patients with severe type of congenital Brown syndrome. Brown syndrome is characterized by hypotropia in primary position and limitation of elevation in adduction more than -4.
Materials And Methods: Fourteen consecutive patients with severe congenital Brown syndrome underwent superior oblique split lengthening surgery (10 mm). The amount of hypotropia in primary gaze and the degree of elevation in adduction were compared before and after the surgery. Any surgical complications were also recorded.
Results: Surgery was performed on 15 eyes in 11 female and 3 male subjects. Mean postoperative follow-up time was 12.93 ± 1.79 months (ranging from 10 to 16 months). Average hypotropia in primary gaze improved from 16.2 ± 5.5 prism diopters (range: 10-25 prism diopters) preoperatively to 5.9 ± 4.0 prism diopters (range: 0-18 prism diopters) postoperatively recorded at final follow-up examination (p < 0.001). The limitation in adduction improved from -7.2 ± 4.5 (range: -6 to -8) preoperatively to -1.8 ± 1.3 (range: zero to -5) postoperatively (p < 0.001). No surgical complications were noted.
Conclusion: Superior oblique split lengthening has a significant effect on reducing primary gaze hypotropia and improving elevation in adduction. This technique should be considered for the treatment of patients with severe congenital Brown syndrome.
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http://dx.doi.org/10.3109/09273972.2013.877943 | DOI Listing |
J Dtsch Dermatol Ges
January 2025
Department of Dermatology, Stony Brook University Medical Center, Stony Brook, New York, USA.
Background: Current research on hirsutism reveals disparities and knowledge deficiencies, particularly in underrepresented cohorts. Our objective is to scrutinize demographic variances in hirsutism rates.
Patients And Methods: Using the All of Us database, we conducted a cross-sectional analysis encompassing 172,401 women.
West Afr J Med
September 2024
Department of Ophthalmology, University of Calabar, Calabar, Cross River State, Nigeria.
Background: Strabismus is a potential cause of ocular morbidity.
Objective: The aim of this study was to determine the frequency, types of manifest strabismus and co-morbidities among patients attending a referral paediatric ophthalmology and strabismus clinic in Calabar, Nigeria.
Methods: A retrospective review of case-notes of patients attending the paediatric ophthalmology and strabismus clinic from January 1, 2017 to December 31, 2019 was done.
Ann Med
December 2025
Department of Neurology, Peking University First Hospital, China.
Objective: Whereas a few studies have evaluated vestibular involvement in Fabry disease (FD), the relationship between vestibular/oculomotor abnormalities and disease-specific biomarkers remain unclear. Therefore, we seek to evaluate these quantitatively and analyze their relationship with disease phenotype and biomarkers in FD.
Methods: This cohort study enrolled 37 Chinese FD patients registered in our center.
Genes (Basel)
January 2025
Department of Ophthalmology, Boston Children's Hospital, Boston, MA 02115, USA.
Background/objectives: Strabismus is the most common ocular disorder of childhood. Three rare, recurrent genetic duplications have been associated with both esotropia and exotropia, but the mechanisms by which they contribute to strabismus are unknown. This work aims to investigate the mechanisms of the smallest of the three, a 23 kb duplication on chromosome 4 (hg38|4:25,554,985-25,578,843).
View Article and Find Full Text PDFBiomedicines
December 2024
Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Preeclampsia (preE) is a severe multisystem hypertensive syndrome of pregnancy associated with ischemia/hypoxia, angiogenic imbalance, apolipoprotein E (ApoE)-mediated dyslipidemia, placental insufficiency, and inflammation at the maternal-fetal interface. Our recent data further suggest that preE is associated with impaired autophagy, vascular dysfunction, and proteinopathy/tauopathy disorder, similar to neurodegenerative diseases such as Alzheimer's disease (AD), including the presence of the cis stereo-isoform of phosphorylated tau (cis P-tau), amyloid-β, and transthyretin in the placenta and circulation. This review provides an overview of the factors that may lead to the induction and accumulation of cis P-tau-like proteins by focusing on the inactivation of peptidyl-prolyl cis-trans isomerase (Pin1) that catalyzes the cis to trans isomerization of P-tau.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!