AI Article Synopsis
- Cloned cDNAs were used in studies to examine how two similar genes in fetal rat livers respond to hormones.
- Both the tyrosine aminotransferase gene and gene 33 show increased activity due to hormones like glucocorticoids, insulin, and cAMP around birth.
- The study found that gene 33 responds strongly to these hormones in fetuses, while the aminotransferase gene only starts responding to insulin after birth, suggesting that different genes gain hormone responsiveness at different developmental stages.
Article Abstract
Cloned cDNAs were used in hybridization analyses to assess hormonal responsiveness of two similarly regulated genes in livers of late-term fetal rats. Transcription of the tyrosine aminotransferase gene and of gene 33 (Lee et al.: J Biol Chem 260:16433-16438, 1985) is enhanced by glucocorticoids and by each of the usually antagonistic hormonal agents, insulin and cAMP, in adult liver, and that of both genes is developmentally activated at or just prior to birth. The mRNA of gene 33 was found to be significantly increased by each of the hormonal regulators in livers of fetuses treated in utero. Expression of the nearly silent aminotransferase gene in fetal liver was appreciably increased by cAMP but was refractory to control by either glucocorticoids or insulin; capacity of this gene to respond to insulin was not realized until several days postpartum. The data indicate specificity in the developmental acquisition of the capacity of individual genes to respond to hormonal regulators.
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| http://dx.doi.org/10.1002/jcb.240370211 | DOI Listing |
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