Background: TRAPS, an autosomal dominant autoinflammatory disorder occurs due to mutations of the TNFRSF1A gene. Mutation negative TRAPS (TRAPS like illness) is also known. Anti TNF molecules (etanercept) is the mainstay of therapy.
Case Characteristics: A 11-year-old boy with a 5 year clinical profile indicative of a TRAPS like illness and with negative mutation studies is described. He has been followed up for nearly 2 years after starting etanercept.
Outcome: He had sustained response to etanercept which has subsequently been titrated (0.4 mg/kg subcutaneously every 23-24 days) to keep him symptom free.
Message: Mutation negative cases of TRAPS can be diagnosed with a high index of suspicion. Treatment with etanercept is expensive but possibly intervals between doses could be titrated to reduce cost.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s13312-014-0313-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Language - a vital pill missing in patients' treatment: language barriers during cancer care through the eyes of patients and families.
Int J Qual Stud Health Well-being
December 2025
Department of Geriatric Medicine, Odense University Hospital, Odense, Denmark.
Purpose: When serious illness occurs, effective communication is essential but challenged by language barriers. This study explores how patients with limited Danish proficiency and their families experience language barriers during cancer care in two Danish public hospitals.
Method: Adopting a phenomenological-hermeneutic approach, the study stresses narratives in understanding participants' lived experiences.
Long-Term Pulmonary Sequelae and Immunological Markers in Patients Recovering from Severe and Critical COVID-19 Pneumonia: A Comprehensive Follow-Up Study.
Medicina (Kaunas)
November 2024
Clinic of Infectious Diseases and Dermatovenerology, Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, 01513 Vilnius, Lithuania.
: Severe and critical COVID-19 pneumonia can lead to long-term complications, especially affecting pulmonary function and immune health. However, the extent and progression of these complications over time are not well understood. This study aimed to assess lung function, radiological changes, and some immune parameters in survivors of severe and critical COVID-19 up to 12 months after hospital discharge.
View Article and Find Full Text PDFIncreased cell-free DNA in CSF and serum of hip fracture patients with delirium.
Brain Commun
December 2024
Oslo Center for Clinical Heart Research, Department of Cardiology Ullevaal, Oslo University Hospital, Oslo 0424, Norway.
Delirium is a neuropsychiatric syndrome commonly presenting during acute illness. The pathophysiology of delirium is unknown, but neuroinflammation is suggested to play a role. In this cross-sectional study, we aimed to investigate whether cell-free DNA and markers of neutrophil extracellular traps in serum and CSF were associated with delirium and neuronal damage, assessed by neurofilament light chain.
View Article and Find Full Text PDFDemoralization's link to depression and anxiety symptoms: A network analysis.
J Affect Disord
December 2024
Department of Psychosomatic Medicine and Psychotherapy, University Hospital Münster, Münster, Germany.
Demoralization represents a clinical syndrome conceptualized as maladaptive coping to a stressor associated with discouragement, feelings of hopelessness, helplessness, and a loss of meaning in life. It is a prevalent comorbidity in individuals with severe physical illnesses and affects a substantial proportion of the general population when facing global stressors like the COVID-19 pandemic. The main aim of the study was to test whether demoralization and features of depression and anxiety might reflect distinct entities within the general population, specifically in older adults, and to explore symptom interconnections, using a network psychometrics approach.
View Article and Find Full Text PDFRight para-duodenal hernia related small bowel strangulation in 71 years old male patient managed surgically for small bowel resection and anastomosis:First case report in Somalia.
Int J Surg Case Rep
December 2024
Department of General Surgery, Mogadishu Somali Turkey Recep Tayyip Erdoğan Training and Research Hospital, Mogadishu, Somalia. Electronic address:
Article Synopsis
- - Para-duodenal hernias account for 53% of internal hernias, mostly occurring on the left side, with rare symptoms in adults and a higher prevalence in males; right para-duodenal hernias are particularly uncommon and often discovered during emergency surgeries.
- - A 71-year-old male experienced severe abdominal pain, nausea, and vomiting, leading to a CT scan that identified a right para-duodenal hernia, resulting in an emergency surgery where the hernia was confirmed.
- - Internal hernias, while rare, lead to significant complications like bowel obstruction and ischemia; due to the patient's extensive symptoms at presentation, an exploratory laparotomy was chosen as the surgical approach, ultimately resulting in a full recovery.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!