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Toward the Development of the Trojan Female Technique in Pest Insects: Male-Specific Influence of Mitochondrial Haplotype on Reproductive Output in the Seed Beetle .
Evol Appl
December 2024
Department of Evolutionary Biology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia University of Belgrade Belgrade Serbia.
Biocontrol techniques that impair reproductive capacity of insect pests provide opportunities to control the dynamics of their populations while minimizing collateral damage to non-target species and the environment. The Trojan Female Technique, or TFT, is a method of the trans-generational fertility-based population control through the release of females that carry mitochondrial DNA mutations that negatively affect male, but not female, reproductive output. TFT is based on the evolutionary hypothesis that, due to maternal inheritance of mitochondria, mutations which are beneficial or neutral in females but harmful in males can accumulate in the mitochondrial genome without selection acting against them.
View Article and Find Full Text PDFDependence of NPPS creates a targetable vulnerability in RAS-mutant cancers.
Acta Pharmacol Sin
November 2024
Department of Pharmacology and Chemical Biology, College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
RAS is the most frequently mutated oncoprotein for cancer driving. Understanding of RAS biology and discovery of druggable lynchpins in RAS pathway is a prerequisite for targeted therapy of RAS-mutant cancers. The recent identification of KRAS inhibitor breaks the "undruggable" curse on RAS and has changed the therapy paradigm of KRAS-mutant cancers.
View Article and Find Full Text PDFSocial Reintegration and Stigma Among Childhood Cancer Survivors in West Kenya.
J Adolesc Young Adult Oncol
October 2024
Emma Children's Hospital, Amsterdam UMC, Paediatric Oncology, Vrije Universiteit, Amsterdam, The Netherlands.
Article Synopsis
- The population of childhood cancer survivors in low- and middle-income countries, like Kenya, is growing due to better diagnosis and treatment, but stigma still makes it hard for them to reintegrate into society.
- A study involving 26 young adult survivors revealed that many faced challenges in school, including bullying and missed classes, while most felt they couldn't openly discuss their cancer experiences due to stigma.
- To improve social reintegration, survivors suggested educational outreach in communities and schools, as well as support through counseling and peer groups.
Near-optimal learning of Banach-valued, high-dimensional functions via deep neural networks.
Neural Netw
January 2025
Department of Mathematics, Simon Fraser University, 8888 University Drive, Burnaby BC, Canada, V5A 1S6. Electronic address:
The past decade has seen increasing interest in applying Deep Learning (DL) to Computational Science and Engineering (CSE). Driven by impressive results in applications such as computer vision, Uncertainty Quantification (UQ), genetics, simulations and image processing, DL is increasingly supplanting classical algorithms, and seems poised to revolutionize scientific computing. However, DL is not yet well-understood from the standpoint of numerical analysis.
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