Intestinal macrophages and DCs close the gap on tolerance.

Immunity

Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.

Published: February 2014

CD103(+) dendritic cells (DCs) must acquire soluble food antigens from the gut lumen to induce oral tolerance. In this issue of Immunity, Mazzini et al. (2014), report that CX3CR1(+) macrophages capture such antigen and transfer it to the DCs by a route involving gap junctions.

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Source
http://dx.doi.org/10.1016/j.immuni.2014.01.008DOI Listing

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