AI Article Synopsis
- A simplified synthesis of the macrocyclic core of TMC-95A is presented.
- The process utilizes an efficient organocatalyzed reaction between isatin and dihydroxyacetone derivatives.
- This method also simultaneously forms a biaryl subunit and integrates macrocyclization.
Article Abstract
A concise and straightforward synthesis of the fully elaborated macrocyclic core of TMC-95A is reported. A highly efficient organocatalyzed aldolization between isatin and dihydroxyacetone derivatives and formation of the biaryl subunit with concomitant macrocyclization are the characteristic features of this synthesis.
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| http://dx.doi.org/10.1021/ol403675c | DOI Listing |
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