The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and overall three-dimensional architecture of the genome. However, the mechanisms of such organization at the 'peripheral zone' and the functional significance of these associations are poorly understood. The role these domains play in development and disease is an active and exciting area of research, expanding our knowledge of how the three-dimensional (3D) genome is regulated.
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