AI Article Synopsis
- Accurate detection of high-risk HPV is crucial for effective cervical cancer screening, with notable test agreements reported between Hybrid Capture 2 (hc2) and cobas HPV tests.
- The cobas and Linear Array tests showed very high consistency for HPV16 and HPV18 results, indicating reliability in identifying these specific strains.
- Issues with three hc2-negative vaginal samples highlighted the importance of amplification controls, while no cross-contamination was found during testing.
Article Abstract
The accurate detection and typing of high-risk human papillomavirus (HPV) are critical for cervical cancer screening. The Hybrid Capture 2 (hc2) and cobas HPV tests showed high agreement for cervical samples (94.4%, κ=0.72, n=693) and moderate agreement for vaginal samples (κ=0.62, n=108). The HPV16 and HPV18 results were highly consistent between the cobas and Linear Array tests (κ≥0.96, n=197). Three hc2-negative vaginal samples were repeatedly invalid by the cobas test due to β-globin control failures, highlighting amplification control benefits. No cross-contamination was detected in a challenge experiment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993637 | PMC |
| http://dx.doi.org/10.1128/JCM.03308-13 | DOI Listing |
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