Progressive multifocal leukoencephalopathy (PML)-derived noncoding control region (NCCR) sequences permitted greater early viral gene expression than kidney-associated NCCR sequences. This was driven in part by binding of the transcription factor Spi-B to unique PML-associated Spi-B binding sites. Spi-B is upregulated in developing B cells in response to natalizumab therapy, a known risk factor for PML. Naturally occurring JCV sequence variation, together with drug treatment-induced cellular changes, may synergize to create an environment leading to an increased risk of PML.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993791PMC
http://dx.doi.org/10.1128/JVI.03221-13DOI Listing

Publication Analysis

Top Keywords

gene expression
8
noncoding control
8
control region
8
progressive multifocal
8
multifocal leukoencephalopathy
8
nccr sequences
8
lymphocyte gene
4
expression virus
4
virus noncoding
4
region sequences
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!