AI Article Synopsis
- Researchers developed a method for directly coupling C-H bonds in N(1),N(3)-diphenylmalonamides using chiral organoiodine catalysts.
- The reaction selectively functionalizes four C-H bonds to produce diverse spirooxindoles with high enantioselectivity.
- This study highlights the potential of chiral hypervalent organoiodine reagents as effective alternatives for catalyzing reactions involving less reactive C-H bonds.
Article Abstract
An asymmetric organocatalytic direct C-H/C-H oxidative coupling reaction of N(1),N(3)-diphenylmalonamides has been well established by using chiral organoiodine compounds as catalysts, wherein four C-H bonds were stereoselectively functionalized to give structurally diverse spirooxindoles with high levels of enantioselectivity. More importantly, the findings indicated that chiral hypervalent organoiodine reagents can serve as alternative catalysts for the creation of enantioselective functionalization of inactive C-H bonds.
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| http://dx.doi.org/10.1002/anie.201309967 | DOI Listing |
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