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Cerebral venocclusive disease due to CNS T cell lymphoma.
Neurol Sci
June 2014
Service of Neurology, Hospital Clinico San Carlos, 28040, Madrid, Spain,
Topotecan, thiotepa, and carboplatin for neuroblastoma: failure to prevent relapse in the central nervous system.
Bone Marrow Transplant
February 2006
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
We report on a three-drug myeloablative regimen designed to consolidate remission and to prevent central nervous system (CNS) relapse of high-risk neuroblastoma (NB). Sixty-six NB patients received topotecan 2 mg/m2/day, x 4 days; thiotepa 300 mg/m2/day, x 3 days; and carboplatin approximately 500 mg/m2/day, x 3 days. Post-SCT treatments included radiotherapy, immunotherapy, 13-cis-retinoic acid, +/-oral etoposide.
View Article and Find Full Text PDFClinical aspects of venous thrombophilia.
Pathophysiol Haemost Thromb
October 2003
University of Padua Medical School, Department of Medical and Surgical Sciences, Padua, Italy.
Venous thrombophilia is the result of clotting changes namely of a hypercoagulable state together with blood flow and vessel wall changes. There is no need for all these components to be present in order for thrombosis to occur. As the matter of fact, thrombosis may occur even if only one of these conditions is present.
View Article and Find Full Text PDFAspects concerning busulfan pharmacokinetics and bioavailability.
Leuk Lymphoma
August 1996
Karolinska Pharmacy, Stockholm, Sweden.
Busulfan as a high-dose therapy is an important component of many of the myeloablative regimens for both allogeneic and autologous bone marrow transplantation (BMT) in adults and children. During the last decade, several studies have shown a wide inter- and intra-patient variability of busulfan disposition in adults and children. Some of the factors affecting the interpatient-variability were identified as circadian rhythmicity, age, disease, drug interaction, alteration in hepatic function and recently busulfan bioavailability.
View Article and Find Full Text PDFFive infants from three families died between the ages of 2 and 7 months with venocclusive disease of the liver. No dietary, toxic, or other extrinsic cause was uncovered. In one family the first infant was breast-fed; the second one received no breast milk.
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