The synthesis of new dendrons and their immobilization on collagen patches via thiol-ene photoclick reaction, followed by chemoselective alkoxyamino-carbonyl conjugation to carbohydrates is presented. XPS, FTIR, and ELLA assays confirmed the effectiveness of the collagen multivalent neoglycosylation.
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http://dx.doi.org/10.1021/ol403476z | DOI Listing |
Anal Methods
January 2025
Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Adenosine triphosphate (ATP) is crucial for cellular activity. The need for ATP detection in the field of biomedicine is rapidly increasing. Several biosensor-based approaches have been developed as a result of the growing demand for ATP detection.
View Article and Find Full Text PDFGels
January 2025
Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Chile.
The wound-healing process has usually been related to therapeutic agents with antioxidant properties. Among them, caffeic acid, a cinnamic acid derivative, stands out. However, the use of this natural product is affected by its bioavailability and half-life.
View Article and Find Full Text PDFACS Nano
January 2025
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Cyclophosphamide has a certain therapeutic effect on treating systemic sclerosis (SSc), while difficulties exist in controlling severe systematic side effects and enhancing targeting capacity. Here, inspired from the natural extracellular matrix composition, we propose a cyclophosphamide-encapsulated nanogel based on dendritic polymers polyamidoamine (PAMAM) for SSc treatment. We combine bovine serum albumin and generation 5 (G5) PAMAM dendrimers with polyphenol modification to obtain nanogels featured with antioxidant and anti-inflammatory effects.
View Article and Find Full Text PDFACS Omega
January 2025
Institute of Chemical Process Fundamentals Czech Academy of Sciences, Rozvojová 135, Prague 165 02, Czech Republic.
Efficient and safe carriers of genetic material are crucial for advancing gene therapy. Three new series of cationic dendritic nanocarriers based on a carbosilane scaffold, differentiated by peripheral modifications: saccharide (CS-glyco), amine (CS-N), and phosphonium dendrimers (CS-P) were designed for binding, protecting, and releasing polyanionic compounds like therapeutic siRNA. Besides introducing synthetic methodology, this study brings a unique direct interstructural comparison of 16 dendritic nanovector's characteristics, addressing a gap in typical research that focuses on uniform structural types.
View Article and Find Full Text PDFBiosens Bioelectron
January 2025
Department of Analytical Chemistry, Faculty of Pharmacy, Adiyaman University, Adiyaman, 02040, Türkiye. Electronic address:
Dendrimers enhance the selectivity and sensitivity of sensors through their synthetic, highly branched, three-dimensional structures and large surface area. This unique architecture enables precise functionalization with various recognition elements, significantly improving the specificity and sensitivity of electrochemical sensors for detecting disease markers, biomolecules, and environmental pollutants. Dendrimer-based electrochemical sensors offer promising advancements in healthcare, such as detecting biomarkers for heart disease, monitoring blood glucose levels, and sensitively determining cancer-related proteins.
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