Placing an interpositional fat graft over the dura has been practiced to prevent sciatica due to nerve tethering from scar. We assessed feasibility, outcomes, and complications of free fat grafts in patients undergoing lumbar microdiscectomy for herniated discs using an access cannula. Retrospective review of prospectively collected data on 69 consecutive patients: those who received autologous fat graft (Group I) and those who did not (Group II). Clinical evaluation of leg pain and nerve tension sign was performed in the immediate postoperative period and at 1 month, 6 months, 12 months, and 24 months. The combined visual analog scale (VAS) scores for leg pain improved from 8.3 preoperatively to 1.3 (P < 0.5). The average VAS score for leg pain was 1.4 (0 to 3) in Group I and 1.3 (0 to 3) in Group II (P > 0.05). Ninety-one percent had resolution of their leg pain immediately postop and 96% at final follow-up. This study found no increased complications with the use of fat graft, but no clinical benefit, therefore the use of fat graft should be discouraged. The potential complication with the use of fat graft is the "mass effect" on the dura, and therefore, the width of the graft should be <1 cm.
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J West Afr Coll Surg
July 2024
Department of Surgery, Faculty of Clinical Sciences, Usmanu Danfodiyo University, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.
Background: Necrotizing fasciitis (NF) is a severe soft tissue infection typified by swiftly spreading necrosis of the fascia and subcutaneous fat with successive necrosis of the skin which affects all age groups.
Objective: To compare the clinical presentation and treatment outcome of NF between children and adults.
Materials And Methods: A prospective descriptive study of all patients presenting with NF to the (Usmanu Danfodiyo Univrersity Teaching Hospital, Sokoto), from September 2018 to August 2019.
J Diabetes Metab Disord
June 2025
Institute of Science, Nirma University, Ahmedabad, Gujarat 382481 India.
Objectives: To investigate the impact of diet-induced gut microbiota alterations on type 2 diabetes and assess the therapeutic potential of Fecal Microbiota Transplantation (FMT) in restoring a balanced gut microenvironment.
Methods: To induce type 2 diabetes, rats were fed a high-sugar high-fat diet (HSFD) for 90 days. After diabetes induction, animals were divided into an HSFD control group, a metformin group (100 mg/kg), and an FMT group (100 mg/kg), receiving treatment for an additional 90 days.
Indian J Plast Surg
December 2024
Department of Plastic Surgery, Contours Plastic and Aesthetic Clinic, Medical College, Gotri, Gujarat, India.
Contemporary medical science has been using fat grafting in aesthetic and reconstructive procedures, consistently achieving successful outcomes. Hansen's disease, caused by , leads to hand deformities due to peripheral neuropathy, resulting in soft-tissue atrophy, volume loss, and compromised hand function. Tendon transfer surgery is a common remedy for functionality, but it often does not address aesthetic concerns and the patient's psychological impact of living with an atrophic hand.
View Article and Find Full Text PDFAdv Nutr
December 2024
Department of Pediatrics, Sichuan Provincial People's Hospital, School of medicine, University of Electronic Science and Technology of China, Chengdu, China; Department of Pediatrics, School of Medicine and Life Science of Chengdu University of Traditional Chinese Medicine, Chengdu, China. Electronic address:
Increasing prevalence of childhood obesity has emerged as a critical global public health concern. Recent studies have challenged the previous belief that obesity was solely a result of excessive caloric intake. Alterations in early-life gut microbiota can contribute to childhood obesity through their influence on nutrient absorption and metabolism, initiation of inflammatory responses, and regulation of gut-brain communication.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Surgery, Division of Transplant Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Central body fat distribution affects kidney function. Abdominal fat measurements using computed tomography (CT) may prove superior in assessing body composition-related kidney risk in living kidney donors. This retrospective cohort study including 550 kidney donors aimed to determine the association between CT-measured abdominal fat areas and kidney function before and after donor nephrectomy.
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