The appearance of a primary germinoma in the central nervous system but not on or near the midline or within the brain is exceptional. It may occur at any age; however, it is rare in patients over 50 years old. Only a handful of cases of germinomas located in the cerebellopontine angle were presented, but to our knowledge, there has been no description of an isolated germinoma in the internal auditory canal. We report a case of germinoma in the internal auditory canal in a 51-year-old man simulating the clinical and radiological characteristics of a vestibular schwannoma.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914568PMC
http://dx.doi.org/10.1155/2014/794158DOI Listing

Publication Analysis

Top Keywords

germinoma internal
12
internal auditory
12
auditory canal
12
vestibular schwannoma
8
germinoma
4
canal mimicking
4
mimicking vestibular
4
schwannoma appearance
4
appearance primary
4
primary germinoma
4

Similar Publications

Article Synopsis
  • - The study explores the potential relationship between chemokines and tumor-infiltrating lymphocytes (TILs) in the prognosis of seminoma, a type of testicular cancer, highlighting the need for more research in this area.
  • - Researchers analyzed samples from 25 seminoma patients and 24 controls, finding that chemokine profiles were significantly different in seminoma compared to normal testis, with notable over-expression in TILs.
  • - Results suggest that the expression of chemokines and the proliferation marker Ki-67 in TILs could be valuable indicators for predicting relapse and understanding seminoma biology, calling for further studies.
View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on a deep learning model called iGNet, which helps doctors tell apart two types of brain tumors: germinomas and nongerminomatous germ cell tumors, so they can treat them better.* -
  • iGNet was trained using information from 280 patients and showed great success in helping doctors diagnose these tumors more accurately during tests.* -
  • The model not only performed well in identifying the tumor types but also matched the doctors' abilities in predicting how well patients would do after treatment.*
View Article and Find Full Text PDF

The authors describe a case of bilateral diffuse paraneoplastic orbital myositis induced by a stage IA left testicular pure seminoma. The patient presented with findings typical of thyroid-associated orbitopathy (TAO) and was thought to have TAO until discovery of the malignancy. Treatment included an urgent orchiectomy, as well as 7 weeks of therapeutic plasma exchange.

View Article and Find Full Text PDF

Expression of CD44 is associated with aggressiveness in seminomas.

Mol Biol Rep

May 2024

Biochemistry, Biochemical Analysis and Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece.

Background: Testicular germ cell tumors (TGCTs) exhibit diverse biological and pathological features and are divided in two main types, seminomas and nonseminomatous germ cell tumors (NSGCTs). CD44 is a cell surface receptor, which is highly expressed in malignancies and is implicated in tumorigenesis affecting cell-matrix interactions and cell signaling.

Methods And Results: Here, we examined the expression of CD44 in tumor cell lines and in patients' material.

View Article and Find Full Text PDF

Aims: To resolve the ongoing controversy surrounding the impact of teratoma (TER) in the primary among patients with metastatic testicular non-seminomatous germ-cell tumours (NSGCT).

Patients And Methods: Using the International Germ Cell Cancer Collaborative Group (IGCCCG) Update Consortium database, we compared the survival probabilities of patients with metastatic testicular GCT with TER (TER) or without TER (NTER) in their primaries corrected for known prognostic factors. Progression-free survival (5y-PFS) and overall survival at 5 years (5y-OS) were estimated by the Kaplan-Meier method.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!