Estimation of sparse covariance matrices and their inverse subject to positive definiteness constraints has drawn a lot of attention in recent years. The abundance of high-dimensional data, where the sample size () is less than the dimension (), requires shrinkage estimation methods since the maximum likelihood estimator is not positive definite in this case. Furthermore, when is larger than but not sufficiently larger, shrinkage estimation is more stable than maximum likelihood as it reduces the condition number of the precision matrix. Frequentist methods have utilized penalized likelihood methods, whereas Bayesian approaches rely on matrix decompositions or Wishart priors for shrinkage. In this paper we propose a new method, called the Bayesian Covariance Lasso (BCLASSO), for the shrinkage estimation of a precision (covariance) matrix. We consider a class of priors for the precision matrix that leads to the popular frequentist penalties as special cases, develop a Bayes estimator for the precision matrix, and propose an efficient sampling scheme that does not precalculate boundaries for positive definiteness. The proposed method is permutation invariant and performs shrinkage and estimation simultaneously for non-full rank data. Simulations show that the proposed BCLASSO performs similarly as frequentist methods for non-full rank data.
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http://dx.doi.org/10.4310/sii.2013.v6.n2.a8 | DOI Listing |
J Electrocardiol
January 2025
University of Rochester School of Nursing, NY, USA; University of Rochester Medical Center, NY, USA.
Background: Identifying patients with low left ventricular ejection fraction (LVEF) in the emergency department using an electrocardiogram (ECG) may optimize acute heart failure (AHF) management. We aimed to assess the efficacy of 527 automated 12‑lead ECG features for estimating LVEF among patients with AHF.
Method: Medical records of patients >18 years old and AHF-related ICD codes, demographics, LVEF %, comorbidities, and medication were analyzed.
J Vasc Access
January 2025
The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, China.
Objective: This study aims to develop a risk assessment model for predicting haemodialysis access dysfunction and to construct a nomogram.
Method: The clinical data of patients with haemodialysis access dysfunction treated at our hospital from October 2020 to January 2024 were retrospectively analysed. The least absolute shrinkage and selection operator regression method was used to filter variables and select predictors, while Cox regression was applied to filter variables and construct a nomogram.
EClinicalMedicine
February 2025
Department of Rehabilitation Medicine, Third Affiliated Hospital of Soochow University, Changzhou, China.
Background: Traumatic brain injury (TBI) is a significant public health issue worldwide that affects millions of people every year. Cognitive impairment is one of the most common long-term consequences of TBI, seriously affect the quality of life. We aimed to develop and validate a predictive model for cognitive impairment in TBI patients, with the goal of early identification and support for those at risk of developing cognitive impairment at the time of hospital admission.
View Article and Find Full Text PDFBMC Womens Health
January 2025
Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Background: Cuproptosis is a novel form of cell death, acting on the tricarboxylic acid cycle in mitochondrial respiration and mediated by protein lipoylation. Other cancer cell death processes, such as necroptosis, pyroptosis, and ferroptosis, have been shown to play crucial roles in the therapy and prognosis of ovarian cancer. However, the role of cuproptosis in ovarian cancer remains unclear.
View Article and Find Full Text PDFBehav Res Methods
January 2025
Methods Center, Eberhard Karls University of Tübingen, Haußerstr. 11, 72076, Tübingen, Germany.
Due to the increased availability of intensive longitudinal data, researchers have been able to specify increasingly complex dynamic latent variable models. However, these models present challenges related to overfitting, hierarchical features, non-linearity, and sample size requirements. There are further limitations to be addressed regarding the finite sample performance of priors, including bias, accuracy, and type I error inflation.
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