Stevens-Johnsons Syndrome (SJS) is an immune-complex-mediated hypersensitivity reaction and has been linked as an adverse side effects to many drugs. Lamotrigine, an anticonvulsive medication and also a commonly used mood stabiliser, can be associated with this adverse reaction. Although this has not been reported very commonly , SJS has high mortality and morbidity and requires careful attention as the use of Lamotrigine is increasing in clinical practice. We present a case where the patient developed Stevens - Johnson Syndrome three weeks after being started on Lamotrigine. The case is discussed for its relevance to the use of Lamotrigine which is currently prescribed very commonly in psychiatric practices.
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http://dx.doi.org/10.12669/pjms.296.4385 | DOI Listing |
Background: There is low-certainty evidence on the impact of extended pharmacological prophylaxis on venous thromboembolism-associated morbidity and mortality. The aim of this study was to determine the efficacy and safety of extended prophylaxis after major abdominopelvic surgery for the prevention of clinically relevant venous thromboembolism after hospital discharge.
Methods: CArdiovaSCulAr outcomes after major abDominal surgEry (CASCADE) was a prospective, international, cohort study into which consecutive adult patients undergoing major abdominopelvic surgery were enrolled (January-May 2022).
Surg Endosc
March 2025
Department of Surgery, Comprehensive Hernia Program, Indiana University School of Medicine, 545 Barnhill Dr., EH 121, Indianapolis, IN, 46202, USA.
Background: Smoking, obesity, diabetes mellitus, and COPD are known risk factors for surgical site occurrences (SSO) following open ventral hernia repair. However, little evidence exists on whether these factors also significantly impact SSO after robotic hernia repair. This is a particularly important distinction because robotic approaches have been associated with fewer wound complications.
View Article and Find Full Text PDFExplor Res Clin Soc Pharm
March 2025
Department of Pharmacology, Pt. J.N.M. Medical College, Raipur, Chhattisgarh, India.
Background: Serious Adverse Drug Reactions (ADRs) represent a critical challenge in contemporary healthcare, necessitating comprehensive investigation and analysis. Within Central India, where healthcare systems grapple with unique demographic, epidemiological, and infrastructural dynamics, understanding the landscape of serious ADRs is paramount.
Objective: This study aimed to evaluate serious ADRs related to age, gender, most implicated class of drugs & single drug, hospital admission, most affected system organ classes, causality and outcome of reactions and fatalities.
J Pharm Bioallied Sci
December 2024
Department of Diagnostic and Surgical Dental Sciences, College of Dentistry/Gulf Medical University, Ajman, UAE.
Stevens-Johnson syndrome (SJS) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome are rare conditions, representing severe hypersensitivity reactions with significant oral presentations. SJS is an uncommon but severe variant of erythema multiforme, presenting skin and mucosal eruptions that can be potentially fatal. DRESS syndrome, similarly, involves a severe hypersensitivity reaction characterized by fever, rash, and organ involvement.
View Article and Find Full Text PDFJ Burn Care Res
March 2025
Department of Surgery, MetroHealth Medical Center, Cleveland, Ohio, United States.
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis are severe mucocutaneous reactions with high morbidity and mortality, most commonly triggered by prescribed medications. Here, we report a case of a 33-year-old female who developed Stevens-Johnson/Toxic Epidermal Necrolysis after receiving an IV vitamin infusion containing glutathione, vitamin C, and vitamin D. While not commonly associated with the development of Stevens-Johnson Syndrome glutathione has been previously reported to have been the inciting agent in Stevens-Johnson Syndrome cases.
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