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Development of a Simultaneous Analytical Method for Amines Corresponding to 10 Typical Nitrosamines.
ACS Omega
January 2025
Towa Pharmaceutical Co., Ltd., 2-11 Shinbashi-cho, Kadoma, Osaka 571-8580, Japan.
Regulatory authorities in various countries have successively issued notices and guidance to pharmaceutical manufacturers and distributors to evaluate the risk of contamination of nitrosamines in pharmaceutical products and to take appropriate measures. Analysis of nitrosamines in pharmaceutical products is not easy due to the large number of foreign substances, and the risk of contamination is determined by first conducting a desk investigation of the manufacturing process of the APIs or pharmaceutical products. However, a desk investigation may miss the risk since this method is not based on actual measurements.
View Article and Find Full Text PDFAn Invasive Solitary Fibrous Tumor/Hemangiopericytoma Originating From the Falx: A Case Report.
Cureus
December 2024
Neurosurgery, Npistanbul Brain Hospital, Istanbul, TUR.
Intracranial solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) are rare, aggressive tumors typically found along the dural sinuses. Despite their aggressive nature, complete surgical resection remains the most significant factor in reducing recurrence and improving survival. Here, we present the case of a 32-year-old male patient who presented with a new-onset headache and vertigo.
View Article and Find Full Text PDFClinical Implications of Breast Cancer Intrinsic Subtypes.
Adv Exp Med Biol
January 2025
Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
Estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) breast cancers have different genomic architecture and show large-scale gene expression differences consistent with different cellular origins, which is reflected in the luminal (i.e., ER+) versus basal-like (i.
View Article and Find Full Text PDFAneurysm at the Trunk of the Medial-Type Persistent Trigeminal Artery Associated with Facial Pain : A Rare Case Report.
J Korean Neurosurg Soc
January 2025
Department of Neurosurgery, Daejeon St. Mary's Hospital, The Catholic University of Korea, Daejeon, Korea.
Persistent trigeminal artery (PTA) is the most common residual manifestation of persistent carotid-vertebrobasilar anastomosis, with the medial-type (intrasellar or sphenoidal) PTA being exceptionally rare. Aneurysms originating from the PTA trunk are not common. We present a unique case of an aneurysm located at the trunk of the medial-type PTA in a patient presenting with trigeminal neuralgia who successfully received endovascular treatment.
View Article and Find Full Text PDFLess toxic combined microplastics exposure towards attached Chlorella sorokiniana in the presence of sulfamethoxazole while massive microalgal nitrous oxide emission under multiple stresses.
J Hazard Mater
January 2025
MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, PR China.
Microalgae-based wastewater treatment could realize simultaneous nutrients recovery and CO sequestration. However, impacts of environmental microplastics (MPs) and antibiotic co-exposure on microalgal growth, nutrients removal, intracellular nitric oxide (NO) accumulation and subsequent nitrous oxide (NO) emission are unclarified, which could greatly offset the CO sequestration benefit. To reveal the potential impacts of environmental concentrations of MPs and antibiotic co-exposure on microalgal greenhouse gas mitigation, this study investigated the effects of representative MPs (PE, PVC, PA), antibiotic sulfamethoxazole (SMX), and nitrite (NO-N) in various combinations on attached Chlorella sorokiniana growth, nutrients removal, anti-oxidative responses, and NO emission originated from intracellular NO build-up.
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