The paper describes the development of implantable and insertable drug delivery systems (IDDS) from their early stage in the 1960s until the current stage in the 2010s. It gives a detailed summary of non-degradable and biodegradable systems and their applications in different areas such as vascular disease treatment, birth control, cancer treatment, and eye disease treatment. It also describes the development of various implantable pump systems and some other atypical IDDS, the challenges and the future of IDDS.
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| http://dx.doi.org/10.1016/j.jconrel.2014.02.006 | DOI Listing |
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Racial Differences in Device-Detected Incident Atrial Fibrillation.
JACC Clin Electrophysiol
November 2024
Division of Cardiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address:
Background: Prior research suggests Black individuals have a lower risk of atrial fibrillation (AF) than White individuals, but this may be related to the underdetection of AF. Whether this trend persists using highly sensitive methods of AF diagnosis has not been well-studied.
Objectives: The objective of this study was to use cardiac implantable electronic devices (CIEDs) capable of AF diagnosis to compare AF incidence between Black and White individuals.
Aims: We aim to evaluate the incidence of atrial fibrillation (AF) in a large real-world cohort of patients implanted with an insertable cardiac monitor (ICM) who had a clinical history of symptomatic heart failure (HF) with reduced or preserved left ventricular ejection fraction (LVEF).
Methods: Patients with an ICM and a history of HF events were identified from the Optum® de-identified Electronic Health Record dataset merged with an ICM device dataset collected during 2007-2021. All ICM-detected AF episodes that were available with ≥30-s of ECG at onset were adjudicated using artificial intelligence (AI model).
Characterization of Post Coronary Artery Bypass Grafting Atrial Fibrillation Patterns: Rationale and Design of an Investigator-Initiated Observational Study.
Am J Cardiol
January 2025
Department of Cardiac Surgery, LMU University Hospital, LMU Munich, Munich, Germany; DZHK (German Centre for Cardiovascular Research) partner site Munich Heart Alliance, Munich, Germany.
Article Synopsis
- - New-onset postoperative atrial fibrillation (POAF) is common after cardiac surgery, particularly coronary artery bypass grafting (CABG), with an estimated incidence of about 30%, but it’s often temporary and under-detected.
- - Previous studies on POAF have used intermittent monitoring techniques that may miss many cases, leading to inaccurate assessments of how often arrhythmias occur post-surgery.
- - The CABG-AF study aims to get a clearer picture of AF incidence and patterns after CABG by using continuous monitoring with an insertable cardiac device in 196 patients, tracking episodes over a planned follow-up of three years.
Pseudomonas monteilii bacteremia and sepsis following insertable cardiac monitor implantation: a case report.
J Med Case Rep
October 2024
Division of Cardiology, Department of Internal Medicine, Uijeongbu Eulji University Hospital, 712, Dongil-Ro, Uijeongbu-Si, Gyeonggi-do, 11759, Republic of Korea.
Background: Insertable cardiac monitor implantation is a simple and safe procedure commonly performed in patients with embolic stroke with undetermined source. Routine periprocedural antibiotic use is not recommended, because infection rate is very low, although some local infection or gram-positive bacteremia have been reported. We report a case of Pseudomonas monteilii sepsis immediately after insertable cardiac monitor implantation.
View Article and Find Full Text PDFRelationship between initial B-type natriuretic peptide levels and detection of atrial fibrillation with an insertable cardiac monitor in cryptogenic stroke: CRYPTON-ICM registry.
Front Neurol
September 2024
Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
Article Synopsis
- High B-type natriuretic peptide (BNP) levels are linked to higher detection rates of new atrial fibrillation (AF) in patients with cryptogenic stroke (CS).
- A study involving 266 patients revealed that those with high BNP levels (≥48.5 pg/mL) had a significantly higher AF detection rate of 53.7% per year compared to only 13.3% in the low-BNP group (≤19.0 pg/mL).
- The optimal BNP cutoff for predicting AF detection was identified as 43.4 pg/mL, highlighting a notable association between BNP levels and AF occurrence in these patients.
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