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The liver lymphatic system plays a critical role in maintaining interstitial fluid balance and immune regulation. Efficient lymphatic drainage is essential for liver homeostasis, but its role in liver disease progression remains poorly understood. In cirrhosis, lymphangiogenesis initially compensates for increased lymph production, but impaired lymphatic drainage in advanced stages may lead to complications such as ascites and portal hypertension.
View Article and Find Full Text PDFLaparoscopic Excision of a Large Intra-abdominal Cystic Lymphangioma in a Six-Month-Old Infant.
Cureus
December 2024
Pediatric Surgery, Panagiotis and Aglaia Kyriakou Children's Hospital, Athens, GRC.
Lymphatic malformation is a rare vascular anomaly caused by abnormal lymphatic system development during embryogenesis. Intra-abdominal lymphatic malformations are uncommon in children, and surgical excision is considered the gold standard for treatment. However, few reports of minimally invasive laparoscopic approaches have been documented.
View Article and Find Full Text PDFEGR1 inhibits clear cell renal cell carcinoma proliferation and metastasis via the MAPK15 pathway.
Oncol Res
January 2025
Department of Urology, Shenzhen Longhua District Central Hospital, Shenzhen, 518110, China.
Background: Clear cell renal carcinoma (ccRCC), the leading histological subtype of RCC, lacks any targeted therapy options. Although some studies have shown that early growth response factor 1 (EGR1) has a significant role in cancer development and progression, its role and underlying mechanisms in ccRCC remain poorly understood.
Methods: The Cancer Genome Atlas (TCGA) database was utilized to examine the expression of EGR1 in ccRCC.
Basophil-Derived IL-4 Production and Its Potential Pro-Tumoural Role in Th2-Polarisation Within Sentinel Lymph Nodes of Primary Cutaneous Melanoma.
Exp Dermatol
January 2025
Department of Dermatology, Kansai Medical University, Hirakata, Osaka, Japan.
Chronic inflammation in the tumour microenvironment (TME) via Th2-polarisation promotes melanoma progression and metastasis, making it a target for immunotherapy. Interleukin (IL)-4 is considered essential for Th2-polarisation in the TME; however, its source remains unknown. Basophils have been postulated as one of its sources.
View Article and Find Full Text PDFKushenol O Regulates GALNT7/NF-κB axis-Mediated Macrophage M2 Polarization and Efferocytosis in Papillary Thyroid Carcinoma.
Phytomedicine
January 2025
The Department of General Surgery, Zhongshan City People's Hospital, Zhongshan, Guangdong Province, 528400, China. Electronic address:
Background: The incidence of papillary thyroid carcinoma (PTC) is on the rise globally. It is frequently associated with early lymphatic metastasis, and the poor prognosis tends to be poor once metastasis or recurrence occurs, even with current treatment modalities. Kushenol O, a novel extract derived from Sophora flavescens, has shown remarkable anticancer properties.
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