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DTPA and anti-inflammatory drug associations to alleviate Pu-induced response of macrophages in vitro.
Toxicol In Vitro
January 2025
Atomic Energy and Alternative Energies Commission (CEA), Laboratory of Radiotoxicology, CEA, Paris-Saclay University, Bruyères-le-Châtel, France.
Internal contamination by inhalation of plutonium poorly soluble compounds leads to their long time retention in alveolar macrophages inducing delayed pathology development. As previous studies highlighted co-localization of retained Pu and inflammatory lesions, this study was designed to assess the combined effect of the reference treatment (DTPA) and anti-inflammatory drugs on Pu-induced early response of macrophages in vitro. Pu colloids, mimicking poorly soluble Pu, were characterized using filtration and solid-state nuclear track detectors CR39.
View Article and Find Full Text PDFLipid accumulation product mediating the association between uranium and cerebrovascular diseases mortality: Evidence from National Health and Nutrition Examination Survey.
Medicine (Baltimore)
December 2024
Xiangya School of Medicine, Central South University, Changsha, China.
This study investigated the potential association between uranium exposure and mortality from cerebrovascular diseases, with a focus on the mediating effects of lipid indicators. Employing recommended sampling weights to account for National Health and Nutrition Examination Survey' complex survey design, this analysis drew from data collected between 2005 and 2016. The study examined the impact of uranium on mortality from cerebrovascular diseases using various statistical approaches, including Cox regression to assess linear relationships within metal mixtures.
View Article and Find Full Text PDFDistribution of plutonium and radium in the human heart.
J Radiol Prot
December 2024
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, UNITED STATES.
Since 1968, the United States Transuranium and Uranium Registries (USTUR) has studied the biokinetics and tissue dosimetry of uranium and transuranium elements in nuclear workers. As part of the USTUR collaboration with the Million Person Study (MPS) of Low-Dose Health Effects, radiation dose to different parts of the human heart is being estimated for workers with documented intakes of 239Pu or 226Ra. The study may be expanded for workers with intakes of 238U and other radionuclides.
View Article and Find Full Text PDFSpecies-specific trends of plutonium, radiocesium, and potassium-40 levels in three fish species of the Yenisei river (Siberia, Russia).
J Environ Radioact
December 2024
All-Russian Research Institute for Silviculture and Mechanization of Forestry, 15 Institutskaya str., Pushkino, 141202, Russia.
Article Synopsis
- * Results indicate no increase in plutonium levels in fish after major discharges from 2018-2020, but grayling had significantly higher Pu concentrations due to their diet of benthic invertebrates, while larger pike showed increasing Pu levels.
- * High concentrations of radiocesium and potassium were found in pike, attributed to biomagnification, leading to potential ecological risk assessments and a foundation for future research on radionuclides in freshwater ecosystems.
Modelling of constant and realistic chronic intake scenarios and their implications.
Radiat Prot Dosimetry
December 2024
Radiation Safety Systems Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
Chronic inhalation intake of radionuclides is possible for radiation workers in the nuclear industry. The International Commission on Radiological Protection (ICRP) provides organ retention fractions as well as daily urinary and fecal excretion for chronic intake of various radionuclides. In this study, organ retention fractions and daily urinary excretion for chronic intake were estimated for constant chronic intake (CCI) and realistic chronic intake (RCI) scenarios.
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