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Why do patients with isolated PCL rupture experience no subjective knee joint instability during walking? An biomechanical study.

Front Bioeng Biotechnol

January 2025

Department of Orthopaedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical Universit, Guangzhou, China.

Objective: The aim of this study is to assess the kinematic changes in the knee joint during walking in patients with isolated PCL-deficiency (PCLD) to determine the presence of walking-related joint instability (mechanical instability-abnormal displacement form structural damage). Additionally, the study seeks to provide biomechanical insights into the observed differences between subjective and objective assessments.

Methods: 35 healthy volunteers and 27 patients with isolated PCLD (both involved and uninvolved sides) were included in the study.

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Background: Dachaihu decoction (DCHD) is a common Chinese medicine formula against sepsis-induced acute lung injury (SALI). PANoptosis is a novel type of programmed cell death. Nevertheless, The mechanisms of DCHD against SALI via anti-PANoptosis remains unknown.

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Background: Optic atrophy (OA) is primarily caused by damage to the retinal pathway system, including widespread degeneration of retinal ganglion cells and axons, leading to visual impairment and blindness. Despite its clinical significance and diverse etiological factors, there is currently a lack of comprehensive bibliometric analyses exploring research trends and hotspots within this field.

Method: This study retrieved relevant literature on OA published between 2003 and 2023 from the Web of Science Core Collection database.

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Objectives: Nigeria's doctor shortage is worsening with mass exodus and imbalanced specialty distribution. Anaesthesia faces particularly critical shortages. Medical graduate specialty choices have a vital impact on the workforce and are essential for healthcare planning.

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Sacubitril/valsartan attenuates inflammation and myocardial fibrosis in Takotsubo-like cardiomyopathy.

J Mol Cell Cardiol

January 2025

Department of Cardiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250031, PR China. Electronic address:

Background: Takotsubo syndrome (TTS) primarily manifests as a cardiomyopathy induced by physical or emotional stress, remains a poorly understood condition with no established treatments. In this study, we investigated the potential of sacubitril/valsartan (sac/val) to increase the survival of TTS patients and reduce inflammation and myocardial fibrosis in experimental models.

Aim: This study aimed to evaluate whether sac/val could improve survival rates in TTS patients, mitigate cardiac remodeling in vivo, and explore its anti-inflammatory and antifibrotic mechanisms in vitro.

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