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Comparison of a Minimally Invasive Transthoracic Approach and a Surgical Method For Intrapleural Injection of Tumor Cells in Mice.
Comp Med
April 2023
Department of Chemistry, Beckman Institute for Advanced Science and Technology, and Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Article Synopsis
- * Traditional injection methods often involve invasive surgeries, which can lead to inflammation and complications like pneumothorax, while nonsurgical methods risk incorrect placement of the injections.
- * The study tested a minimally invasive transthoracic technique (MI-TT) against a surgical approach and found that MI-TT resulted in more consistent tumor placement and higher tumor burden, although further research is needed for validation.
Study of Aqueous Ecballium Elaterium as Fibrinolytic in The Rabbit Model of Intrapleural Empyema.
Niger J Clin Pract
September 2021
Biochemistry, Harran University, Medical School, Thoracic Surgery, Sanliurfa, Dicle University, Medical School, Diyarbakir, Turkey.
Aims: We aimed to investigate of intrapleural use of ecballium elaterium (EE) in a rabbit model empyema.
Methods: An empyema was induced in 21 rabbits after inoculation of Staphylococcus aureus. Glucose levels, pH, lactate dehydrogenase levels, and amounts of pleural drainage were evaluated in addition to pleural and empyema scores.
Optimization of a Luciferase-Expressing Non-Invasive Intrapleural Model of Malignant Mesothelioma in Immunocompetent Mice.
Cancers (Basel)
August 2020
Humanitas Clinical and Research Center - IRCCS -, Via Manzoni 56, 20089 Rozzano (MI), Italy.
Malignant Pleural Mesothelioma (MPM) is an aggressive tumor of the pleural lining that is usually identified at advanced stages and resistant to current therapies. Appropriate pre-clinical mouse tumor models are of pivotal importance to study its biology. Usually, tumor cells have been injected intraperitoneally or subcutaneously.
View Article and Find Full Text PDFEvaluation of the Roflumilast Effect Supplemented with Linezolid in Pleural Empyema in Rats Caused by Intrapleural Staphylococcus aureus Inoculation.
Jpn J Infect Dis
January 2020
Department of Pulmonary Diseases, Ataturk University School of Medicine.
In addition to tube drains, pleural empyema is treated with antibiotics and anti-inflammatory drugs. We aimed to evaluate the anti-inflammatory activity of roflumilast combined with linezolid in a rat model of pleural empyema induced by Staphylococcus aureus. A total of 40 rats were divided into 7 groups: sham (n = 4), S.
View Article and Find Full Text PDFProlonged retention of liposomes in the pleural cavity of normal mice and high tumor distribution in mice with malignant pleural effusion, after intrapleural injection.
Int J Nanomedicine
August 2019
Foundation for Research and Technology Hellas, Institute of Chemical Engineering Sciences (FORTH/ICE-HT), Rio, Greece.
Intrapleural administration of compounds is a lung targeted, innovative therapeutic strategy for mesothelioma, which can be refined as a route for drug delivery that minimizes the potential for systemic toxicity. However, little is currently known about the retention of liposomal drugs at the site, after such topical administration. To evaluate the retention of liposomes in lungs following intrapleural injection, and how this might be modulated by liposome properties and disease progression.
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