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Background: Duodenal and gastric content of mucosal enzymes in duodenal ulcer (DU) patients differs from that of controls. The purpose of this study has been to examine the effect of omeprazole and eradication of Helicobacter pylori on mucosal enzymes in DU patients.
Methods: The enzyme activities of seven gastric and duodenal mucosal marker enzymes from the brush border, lysosomes, and mitochondria have been studied.
Processing of vasoactive intestinal peptide and transferrin in human cancerous colonic cells.
Peptides
August 1992
Laboratoire de Recherches sur les Peptides Neurodigestifs et le Diabète, INSERM U 55, Paris, France.
Endocytosis of vasoactive intestinal peptide (VIP) and of transferrin (Tf) was comparatively studied in human cancerous colonic HT-29 cells. Cellular depletion in potassium inhibits the internalization of VIP (23%) and to a greater extent (42%) that of Tf. This indicates that clathrin-coated pits are also involved, at least in part, in VIP uptake.
View Article and Find Full Text PDFEffect of misoprostol and antacids on gastric and duodenal mucosal enzyme activities in duodenal ulcer patients.
Scand J Gastroenterol
April 1991
Mandal Hospital, Norway.
The activities of 11 marker enzymes from the gastric and duodenal mucosa were determined in 15 patients with active duodenal ulcer disease before therapy, after 4 weeks of therapy with the prostaglandin E1 analogue misoprostol, 400 micrograms twice daily, and after another 4 weeks without any therapy. Another 15 patients were given a high-dose liquid antacid regimen. The activities were measured in homogenized material obtained with forceps through an endoscope.
View Article and Find Full Text PDFEnzyme activities in biopsy specimens from human gastric mucosa.
Scand J Gastroenterol
November 1986
The distribution of a series of marker enzymes in the gastric mucosa was studied by analysis of homogenized biopsy specimens from the lesser and greater curvature of the body and antrum, respectively, obtained from 11 control patients. The activities varied significantly between the regions for the membrane enzymes lactase (p less than 0.0001), neutral-alpha-glucosidase (p less than 0.
View Article and Find Full Text PDFBiopsy material of six patients with eosinophilic granuloma (EG) was investigated by electron microscopic and enzyme-histochemical methods for acid phosphatase (AcP), leucyl-beta-naphthylamidase (LA), adenosine triphosphatase, and alpha-naphthyl-acetate esterase (NE). Paraplast sections were used for demonstration of lysozyme with an immunoperoxidase method. Results of staining for these different enzymes suggested the existence of two separate sets of histiocytic cells: one type with "dot-like" AcP staining and negative for NE and lysozyme; and the other with diffuse AcP staining, positive for NE and lysozyme, and often showing signs of phagocytosis.
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