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A type VII-secreted lipase toxin with reverse domain arrangement.
Nat Commun
December 2023
Newcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
The type VII protein secretion system (T7SS) is found in many Gram-positive bacteria and in pathogenic mycobacteria. All T7SS substrate proteins described to date share a common helical domain architecture at the N-terminus that typically interacts with other helical partner proteins, forming a composite signal sequence for targeting to the T7SS. The C-terminal domains are functionally diverse and in Gram-positive bacteria such as Staphylococcus aureus often specify toxic anti-bacterial activity.
View Article and Find Full Text PDF1,8-Cineol (Eucalyptol) Disrupts Membrane Integrity and Induces Oxidative Stress in Methicillin-Resistant .
Antioxidants (Basel)
July 2023
Laboratory of Pharmaceutical, Chemical and Pharmacological Drug Development LR12ES09, Faculty of Phamacy, University of Monastir, Monastir 5000, Tunisia.
Due to the increased emergence of drug-resistant bacteria, the declining efficiency of traditional antimicrobials has generated severe concerns in recent years. Subsequently, more interest in other antimicrobial agents from natural resources draws more attention as an alternative to conventional medications. This study investigated the bactericidal mechanism of monoterpene 1,8-cineol (eucalyptol), a major compound of various essential oils, against methicillin-resistant (MRSA).
View Article and Find Full Text PDFGene expression and cell culture assays reveal cheese isolate Lactococcus lactis MC5 may influence the virulence of Staphylococcus aureus.
Braz J Microbiol
September 2023
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto (FCFRP-USP), Brazil.
Staphylococcus aureus (SA) can thrive in a wide variety of hosts and environments, causing clinical infections and foodborne intoxications. In Brazil, SA is commonly isolated from traditional soft cheeses, especially those prepared from unpasteurized milk. In this research, the isolate S.
View Article and Find Full Text PDFStatins potentiate the antibacterial effect of platelets on .
Platelets
July 2021
IHU Méditerranée Infection, Aix Marseille University, IRD, APHM, MEPHI, Marseille, France.
Platelets have largely demonstrated their implication in anti-infectious immunity. This effect is ensured by the secreted molecules stored mostly in platelet alpha granules. Previous studies have reported that showed sensitivity to this antibacterial effect of platelets.
View Article and Find Full Text PDFThe autophagic response to provides an intracellular niche in neutrophils.
Autophagy
April 2021
Institute of Biology Leiden, Faculty of Science, Leiden University, Leiden, The Netherlands.
is a major human pathogen causing multiple pathologies, from cutaneous lesions to life-threatening sepsis. Although neutrophils contribute to immunity against , multiple lines of evidence suggest that these phagocytes can provide an intracellular niche for staphylococcal dissemination. However, the mechanism of neutrophil subversion by intracellular remains unknown.
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