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Primary gastric T-cell lymphomas (PGTL) are exceedingly rare with an estimated incidence of 0.0091 per 100,000 person-years, affecting mainly elderly males. PGTL can present with a variety of gastrointestinal symptoms, but patients only rarely present with perforation.
View Article and Find Full Text PDFIL-33 and soluble ST2 in follicular fluid are associated with premature ovarian insufficiency.
Front Endocrinol (Lausanne)
December 2024
Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Background: Premature ovarian insufficiency (POI) is a common reproductive disease that is associated with chronic inflammation in ovaries. Interleukin 33 (IL-33) is a pro-inflammatory IL-1 family cytokine, and functions as an alarmin reflecting inflammatory reaction. Our study aimed to investigate levels of IL-33 and its soluble receptor (sST2) in both follicular fluid (FF) and paired serum during different stages of POI, and evaluate their predictive potentials for POI.
View Article and Find Full Text PDFAstaxanthin improves assisted reproductive technology outcomes in poor ovarian responders through alleviating oxidative stress, inflammation, and apoptosis: a randomized clinical trial.
J Ovarian Res
October 2024
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Poorsina Ave, P.O. Box: 1461884513, Tehran, Iran.
Article Synopsis
- Poor ovarian response (POR) affects women over 35 with low ovarian reserve, making it hard to achieve live births; this study tests astaxanthin as a treatment to improve outcomes.
- 60 POR patients underwent a trial, receiving either astaxanthin or a placebo while monitoring various oxidative stress and inflammation markers.
- Results showed that the astaxanthin group had better serum antioxidant levels and lower inflammatory markers, though no main differences were found in follicular fluid; this suggests astaxanthin might help with ovarian response in ART.
Decoding molecular features of bovine oocyte fate during antral follicle growth via single-cell multi-omics analysis†.
Biol Reprod
October 2024
State Key Laboratory of Animal Biotech Breeding, Frontiers Science Center for Molecular Design Breeding (MOE), College of Animal Science and Technology, China Agricultural University, Beijing, China.
Antral follicle size is a useful predictive marker of the competency of enclosed oocytes for yielding an embryo following in vitro maturation and fertilization. However, the molecular mechanisms underpinning oocyte developmental potential during bovine antral follicle growth are still unclear. Here, we used a modified single-cell multi-omics approach to analyze the transcriptome, DNA methylome, and chromatin accessibility in parallel for oocytes and cumulus cells collected from bovine antral follicles of different sizes.
View Article and Find Full Text PDFAGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review.
Clin Gastroenterol Hepatol
August 2024
Digestive Disease Research Center, Medical University of South Carolina, Charleston, South Carolina.
Description: In this Clinical Practice Update (CPU), we will Best Practice Advice (BPA) guidance on the appropriate management of iron deficiency anemia.
Methods: This expert review was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the CPUC and external peer review through standard procedures of Clinical Gastroenterology and Hepatology. These Best Practice Advice (BPA) statements were drawn from a review of the published literature and from expert opinion.
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