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Background: Proton pump inhibitors (PPIs) are commonly used for managing gastroesophageal disorders but concerns about their potential association with increased stroke risk have emerged, especially among patients with pre-existing cardiovascular conditions such as acute coronary syndrome (ACS). This systematic review and meta-analysis aim to assess the risk of stroke associated with PPI use, stratified by the presence or absence of pre-existing CVD.

Methods: This review was conducted following the PRISMA guidelines and included studies up to March 2024 from PubMed, Embase, and Web of Science.

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Background: Vaccine hesitancy is a serious public health problem globally, particularly in low- and middle-income countries like Pakistan. This study aims to determine the vaccination refusal rate, associated factors and perceptions of parents who refused routine immunisation within Peshawar, Khyber Pakhtunkhwa, Pakistan.

Methods: A cross-sectional study conducted in July-2024, among 340 parents of children aged 0-59 months.

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Cannabis consumption and risk of asthma: a systematic review and meta-analysis.

BMC Pulm Med

January 2025

Global Health and Infectious Diseases Control Institute, Nasarawa State University, Keffi, Nigeria.

Background: Cannabis is the third most widely used psychoactive substance globally, and its consumption has been increasing, particularly with the growing trend of legalization for medicinal and recreational use. Recent studies have raised concerns about the potential impact of cannabis on respiratory health, specifically the risk of asthma, a significant public health concern. This systematic review aimed to consolidate research on the association between cannabis use and the risk of asthma.

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A case series on the basic concept and design of removable partial dentures: support and bracing considerations.

BMC Oral Health

January 2025

Department of Removable Prosthodontics, School of Dentistry, Aichi Gakuin University, 2-11 Suemori- dori, Chikusa-ku, Nagoya, Aichi, 464-8651, Japan.

Background: When designing removable partial dentures, maximizing the effectiveness of support and bracing is necessary to minimize denture movement. Therefore, it is essential to emphasize the importance of providing patients with appropriate, safe, and secure removable partial dentures and have clinicians rerecognize the concept and importance of support and bracing. This study aimed to present extension-base removable partial dentures through six specific clinical case series and describe the effect of support and bracing action on denture design, which is essential for denture movement minimization.

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Periapical bone edema volume in 3D MRI is positively correlated with bone architecture changes.

Insights Imaging

January 2025

Diagnostic and Interventional Radiology, University Hospital of Zurich, University Zurich, Zurich, Switzerland.

Objectives: To compare and correlate bone edema volume detected by 3D-short-tau-inversion-recovery (STIR) sequence to osseous decay detected by a T1-based sequence and conventional panoramic radiography (OPT).

Materials And Methods: Patients with clinical evidence of apical periodontitis were included retrospectively and received OPT as well as MRI of the viscerocranium including a 3D-STIR and a 3D-T1 gradient echo sequence. Bone edema was visualized using the 3D-STIR sequence and periapical hard tissue changes were evaluated using the 3D-T1 sequence.

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