Highly diastereoselective addition of alkoxyethynyl aluminium reagents to N-tert-butylsulfinyl aldimines.

Org Biomol Chem

Université Joseph Fourier, Département de Chimie Moléculaire (SERCO), UMR-5250 CNRS, ICMG FR-2607, BP 53, 38041, Grenoble Cedex 9, France.

Published: March 2014

The addition of dimethylaluminium alkoxyacetylides to Ellman's sulfinylimines is described. The reaction proceeds with excellent diastereoselectivity and high yield to produce oxygenated propargylamines in one step starting from simple dichloroenol ethers.

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Source
http://dx.doi.org/10.1039/c3ob42352bDOI Listing

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