Butanol has recently gained increasing interest due to escalating prices in petroleum fuels and concerns on the energy crisis. However, the butanol production cost with conventional acetone-butanol-ethanol fermentation by Clostridium spp. was higher than that of petrochemical processes due to the low butanol titer, yield, and productivity in bioprocesses. In particular, a low butanol titer usually leads to an extremely high recovery cost. Conventional biobutanol recovery by distillation is an energy-intensive process, which has largely restricted the economic production of biobutanol. This article thus reviews the latest studies on butanol recovery techniques including gas stripping, liquid-liquid extraction, adsorption, and membrane-based techniques, which can be used for in situ recovery of inhibitory products to enhance butanol production. The productivity of the fermentation system is improved efficiently using the in situ recovery technology; however, the recovered butanol titer remains low due to the limitations from each one of these recovery technologies, especially when the feed butanol concentration is lower than 1 % (w/v). Therefore, several innovative multi-stage hybrid processes have been proposed and are discussed in this review. These hybrid processes including two-stage gas stripping and multi-stage pervaporation have high butanol selectivity, considerably higher energy and production efficiency, and should outperform the conventional processes using single separation step or method. The development of these new integrated processes will give a momentum for the sustainable production of industrial biobutanol.
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http://dx.doi.org/10.1007/s00253-014-5561-6 | DOI Listing |
Bioresour Technol
December 2024
College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China. Electronic address:
Biotechnol Biofuels Bioprod
November 2024
Chair of Microbiology, Technical University of Munich, Emil-Ramann-Str. 4, 85354, Freising, Germany.
J Biotechnol
September 2024
Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, India. Electronic address:
Cyanobacteria are oxygen-evolving prokaryotes that can be engineered for biofuel production from solar energy, CO and water. Isobutanol (IB) has the potential to serve as an alternative fuel and important chemical feedstock. The research involves engineering Synechocystis sp.
View Article and Find Full Text PDFN Biotechnol
November 2024
School of Life Science, Beijing Institute of Technology, Beijing 100081, China. Electronic address:
D-1,2,4-butanetriol (BT) is a widely used fine chemical that can be manufactured by engineered Escherichia coli expressing heterologous pathways and using xylose as a substrate. The current study developed a glucose-xylose dual metabolic channel system in an engineered E. coli and Combinatorially optimized it using multiple strategies to promote BT production.
View Article and Find Full Text PDFBiotechnol Biofuels Bioprod
June 2024
Department of Biotechnology, University of Chemistry and Technology Prague, Technická 5, 16628, Prague, Czech Republic.
Background: Inhibitors that are released from lignocellulose biomass during its treatment represent one of the major bottlenecks hindering its massive utilization in the biotechnological production of chemicals. This study demonstrates that negative effect of inhibitors can be mitigated by proper feeding strategy. Both, crude undetoxified lignocellulose hydrolysate and complex medium supplemented with corresponding inhibitors were tested in acetone-butanol-ethanol (ABE) fermentation using Clostridium beijerinckii NRRL B-598 as the producer strain.
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