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Identification of immune characteristics of two lung adenocarcinoma subtypes based on immune- and pyroptosis-related genes to improve immunotherapy.
Bull Cancer
January 2025
Department of Respiratory and Critical Care Medicine, Baoji High-Tech Hospital, Baoji, 721000 Shaanxi, China. Electronic address:
Background: Lung adenocarcinoma (LUAD) is the most prevalent histological subtype of lung cancer. Pyroptosis is a programmatic cell death linked to inflammation.
Methods: The data information of 541 LUAD samples and 59 normal samples were obtained from TCGA database.
Higher detectability of amyloid with phenol Congo red compared with alkaline Congo red.
Reumatologia
November 2024
Department of Pathology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Introduction: Amyloidosis is a heterogeneous group of conditions associated with tissue deposition of insoluble abnormal proteins that damage vital organs. Early diagnosis, when the deposits are minimal, determines the prognosis and requires histological confirmation. The commonly adopted gold standard technique is alkaline Congo red (ACR) staining, though its sensitivity is limited.
View Article and Find Full Text PDFConstruction of a risk prediction model for postoperative deep vein thrombosis in colorectal cancer patients based on machine learning algorithms.
Front Oncol
November 2024
Department of Gastrointestinal Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Article Synopsis
- Colorectal cancer is a growing health concern, and patients face a significant risk of developing lower limb deep vein thrombosis (DVT) after surgery.
- The study aimed to create a machine learning model that predicts the likelihood of DVT in these patients to improve treatment and safety during recovery.
- By analyzing data from 429 colorectal cancer patients and using advanced techniques, researchers found that the XGBoost model was the most effective, boasting an impressive AUC of 0.996, indicating its strong predictive capabilities.
Brain and brain blood vessels histological description in autopsies of fetuses/neonates born to mothers with hypertension during pregnancy. A case-control study.
Lancet Reg Health Am
January 2025
Department of Pathology, Hospital Universitario San Ignacio, Bogotá, Colombia.
Background: Children born to women with hypertension during pregnancy have a two to threefold increased risk of developing cognitive disorders compared to children born to women without hypertension. However, structural changes in the central nervous system of these children remain poorly understood. We aim to compare the brain histological findings from autopsies of neonates and fetuses born to women with and without hypertension during pregnancy.
View Article and Find Full Text PDF[Clinicopathological and molecular genetic features of POLE-mutated endometrioid carcinoma].
Zhonghua Bing Li Xue Za Zhi
December 2024
Department of Pathology, the Seventh Medical Center of Peoples's Liberation Army General Hospital, Beijing100700, China.
To investigate the clinicopathological and molecular genetic features of POLE mutant endometrioid carcinoma. Genetic test data of 230 cases of endometrial carcinoma that underwent surgical resection and molecular typing by next generation sequencing in the First Medical Center of Chinese PLA General Hospital from January 2021 to June 2023 were retrospectively analyzed. Seventeen cases of endometrioid carcinoma with POLE mutation were selected.
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