AI Article Synopsis
- The study examined the link between plasma soluble klotho (sKlotho) and pro-endothelin-1 (proET-1) in patients with type 2 diabetes (T2DM) compared to non-diabetics.
- Results showed that T2DM patients had significantly lower sKlotho levels than controls, and a strong inverse correlation between sKlotho and proET-1 was found specifically in T2DM subjects.
- This suggests that sKlotho may play a role in regulating proET-1 levels in T2DM, independent of kidney function.
Article Abstract
Objectives: To study the relationship between plasma soluble klotho (sKlotho) and pro-endothelin-1 (proET-1) in patients with type 2 diabetes (T2DM).
Subjects And Methods: In this cross-sectional study, we recruited 175 T2DM subjects and 56 non-diabetic controls. Plasma sKlotho, proET-1 and extracellular superoxide dismutase (SOD) were measured by ELISA and ILMA, respectively.
Results: Plasma sKlotho level in patients with T2DM was lower compared to that in non-diabetic controls (416.8±148.1 vs. 494.6±134.3 pg/ml, p=0.001) and showed significant interaction with diabetes status in its association with proET-1. Plasma sKlotho was inversely correlated with proET-1 in T2DM (Rho=-0.410, p<0.0001) but not in non-diabetic controls (Rho=0.091, p=0.505). Multivariable linear regression models revealed that sKlotho was independently associated with proET-1 after adjustment for renal filtration function, albuminuria, diabetes duration, HbA1c, systolic and diastolic blood pressure.
Conclusions: Plasma sKlotho was associated with proET-1 independent of renal function in patients with T2DM.
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| http://dx.doi.org/10.1016/j.atherosclerosis.2014.01.024 | DOI Listing |
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