AI Article Synopsis
- - Erectile dysfunction (ED) is a frequent issue following radical prostatectomy (RP), negatively impacting men's quality of life due to nerve damage and muscle issues from surgery.
- - Intraoperative handling of nerves can lead to neuropraxia, causing fibrosis and damage to smooth muscle, which is crucial for erectile function.
- - The study proposes that pioglitazone, an anti-diabetic drug known for its ability to reduce fibrosis and protect blood vessels, may help maintain erectile function after RP.
Article Abstract
Erectile dysfunction (ED) is a common consequence of radical prostatectomy (RP) and can affect a man's long-term quality of life. Intraoperative manipulation of the neurovascular bundle causes neuropraxia with resultant fibrosis and trabecular smooth-muscle damage. Pioglitazone is an anti-diabetic agent with recognized antifibrotic and vasculoprotective properties, which can protect smooth muscle function. We hypothesize that post-RP pioglitazone therapy can help preserve erectile function.
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| http://dx.doi.org/10.1016/j.mehy.2014.01.022 | DOI Listing |
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