Objectives: Some patients with progressive supranuclear palsy (PSP) present with cerebellar dysfunction. Severe degeneration of the cerebellar dentate nucleus (CDN) was evident in these patients. We evaluated signal intensity on MRI in the CDN of PSP patients with or without cerebellar ataxia.
Patients And Methods: We reviewed the clinical histories and brain MRI studies of 28 patients with clinically probable PSP. Three disease control groups were studied: a group of 28 sex- and age-matched patients with Parkinson's disease (PD), a group of 15 patients with multiple system atrophy with predominant parkinsonian features (MSA-P), and 15 control subjects. Turbo spin-echo sequences for T2-weighted images were used using a 1.5T magnetic resonance imager.
Results: Eight patients with PSP (28%) and one patient with MSA-P (6%) had heterogeneous regions in the CDN. This finding was not evident in the patients with PD or controls. Three out of four PSP patients with cerebellar ataxia had heterogeneous regions in the CDN and other one patient with cerebellar ataxia as the initial and principal symptoms had no heterogeneous regions in the CDN.
Conclusion: Heterogeneous regions in the CDN on MRI do not always reflect cerebellar ataxia in PSP patients, and this finding might be an additional marker to support a probable diagnosis of PSP.
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http://dx.doi.org/10.1016/j.clineuro.2013.12.011 | DOI Listing |
Vet Med Sci
January 2025
Department of Veterinary Science, College of Agriculture and Environmental Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Background: Fasciolosis is a prevalent disease that significantly impairs the health and productivity of cattle and causes significant economic damage. Beyond the individually available studies with varying prevalence rates, there are no pooled national prevalence studies on bovine fasciolosis. Therefore, the current study aims to determine the pooled prevalence and economic significance of fasciolosis among cattle in Ethiopia.
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December 2024
Institute for Health and Sport, Victoria University, Melbourne, VIC 3030, Australia.
Background: Breast cancer is a heterogeneous disease with distinct clinical subtypes, categorized by hormone receptor status, which exhibits different prognoses and requires personalized treatment approaches. These subtypes included luminal A and luminal B, which have different prognoses. Breast cancer development and progression involve many factors, including interferon-gamma ().
View Article and Find Full Text PDFScientifica (Cairo)
December 2024
Department of Forest Biometrics, Forest Research and Training Centre, Babarmahal, Kathmandu 44600, Nepal.
The development of a model is highly crucial in cases where there are intricate geographical features, and conducting a forest inventory is both time-consuming and expensive, requiring significant manual effort for measurement. Acquiring reliable data regarding the forest's condition and future progression is essential for making informed decisions about its management. Therefore, this research aimed to create an individual tree diameter growth model specifically for (B.
View Article and Find Full Text PDFBur., a versatile plant with medicinal, edible, landscaping, and ecological applications, holds significant economic value and boasts a long-standing history of utilization in China. Despite its robust adaptability, rapid growth, and extensive distribution, the current research gap concerning the physiological mechanisms underlying stem cutting propagation hampers the development of efficient strategies for commercial-scale propagation of , particularly for large-scale cultivation.
View Article and Find Full Text PDFJ Diabetes Res
December 2024
Department of Medicine, Faculty of Medicine, University of Málaga, Málaga, Spain.
Olfactory dysfunction and cognitive impairment (CI) have been associated with Type 2 diabetes (T2DM), but the mechanisms underlying this association are broadly unknown. This systematic review tends to investigate the relationship between the onset of olfactory dysfunction and CI in patients with T2DM and to explore the potential role of olfactory dysfunction as an early diagnosis biomarker of CI. We conducted a systematic review consulting PubMed and Scopus.
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