Introduction: Spinal tuberculosis (TB) accounts for 50% or more of skeletal tuberculosis. MRI is a helpful tool for spinal TB. MR findings in spinal TB however, may have several different patterns.
Methods: The MRI features of spinal TB and classification as usual and unusual findings are reported. The MR images in 52 proven spinal TB patients in Srinagarind Hospital from 1996 to 2005 were retrospectively reviewed.
Results: There were five characteristics of unusual manifestations, including multiple skip lesions, vertebral body involvement, lamina and spinous process involvement, single vertebral collapse, and intramedullary tuberculoma. The skip lesion of spinal TB was the only distribution pattern significantly identified as being an unusual characteristic by multiple logistic regression.
Conclusion: The most common unusual pattern of spinal TB is skip lesions (11.5%). The distribution of this pattern is statistically significant as an important MRI feature for defining unusual spinal TB.
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http://dx.doi.org/10.1111/1754-9485.12157 | DOI Listing |
Clin Dysmorphol
December 2024
Department of Pediatric Genetics.
Introduction: Spondyloepimetaphyseal dysplasia with joint laxity type 1 (SEMD-JL1) is an extremely rare skeletal dysplasia belonging to a group of disorders called linkeropathies. It is characterized by skeletal and connective tissue abnormalities. Biallelic variants in genes encoding enzymes that synthesize the tetrasaccharide linker region of glycosaminoglycans lead to linkeropathies, which exhibit clinical and phenotypic features that overlap with each other.
View Article and Find Full Text PDFActa Pharm Sin B
December 2024
Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China.
Spinal microglia and astrocytes are both involved in neuropathic and inflammatory pain, which may display sexual dimorphism. Here, we demonstrate that the sustained activation of spinal astrocytes and astrocyte-derived interleukin (IL)-17A promotes the progression of mouse bone cancer pain without sex differences. Chemogenetic or pharmacological inhibition of spinal astrocytes effectively ameliorates bone cancer-induced pain-like behaviors.
View Article and Find Full Text PDFJ Transl Med
January 2025
Department of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China.
Background: Spinal cord injury (SCI) triggers a complex inflammatory response that impedes neural repair and functional recovery. The modulation of macrophage phenotypes is thus considered a promising therapeutic strategy to mitigate inflammation and promote regeneration.
Methods: We employed microarray and single-cell RNA sequencing (scRNA-seq) to investigate gene expression changes and immune cell dynamics in mice following crush injury at 3 and 7 days post-injury (dpi).
BMC Health Serv Res
January 2025
The University of Sydney, Faculty of Medicine and Health, School of Rural Health, Orange, NSW, 2800, Australia.
Background: Low-value care refers to the provision of health services that confer little or no benefit to patients, or have the potential to incur unwarranted harms. A breadth of literature exists investigating geographical variations in rates of potential low-value interventions for musculoskeletal pain. This scoping review aimed to examine the provision of low-value care for osteoarthritis and lower back pain by degree of rurality (e.
View Article and Find Full Text PDFBMC Med Educ
January 2025
Department of Science and Education, Zhuzhou 331 Hospital, Zhuzhou, China.
Background: Case-Based Learning (CBL) and Problem-Based Learning (PBL) are popular methods in medical education. However, we do not fully understand how they affect the clinical thinking skills of Assistant General Practitioner (AGP) trainees. This randomised controlled trial aimed to assess the effectiveness of combining CBL and PBL and compare their impact on the clinical thinking skills of AGP trainees with that of traditional lecture-based learning (LBL).
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