AI Article Synopsis
- Silibinin, a flavonoid from milk thistle, shows anti-cancer properties by inducing cell death in human colon cancer HT-29 cells.
- In experiments, treating the cells with increasing concentrations of silibinin for up to 72 hours led to a significant decrease in cell viability, peaking at a 78% reduction.
- The study confirmed that silibinin's effectiveness in killing cancer cells increases over time, supporting its potential as an anticancer agent in line with previous research findings.
Article Abstract
Background: Silibinin a flavonoid from milk thistle (Silybum marianum) exhibit a variety of pharmacological actions, including anti-proliferative and apoptotic activities against various types of cancers in intact animals and cancer cell lines. In the present study, the effect of silibinin on human colon cancer HT-29 cells was studied.
Method: Incubations of cells with different silibinin concentrations (0.783-1,600 ug/ml) for 24, 48 or 72 h showed a progressive decline in cell viability.
Results: Loss of cell viability was time dependent and optimum inhibition of cell growth (78%) was observed at 72 h. Under inverted microscope, the dead cells were seen as cell aggregates. IC50 (silibinin concentration killing 50% cells) values were 180, 110 and 40 ug/ml at 24, 48 and 72 h respectively.
Conclusion: These findings re-enforce the anticancer potential of silibinin, as reported earlier for various other cancer cell lines (Ramasamy and Agarwal (2008), Cancer Letters, 269: 352-62).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3305/nh.2014.29.2.7080 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dual functions of silibinin in attenuating aortic dissection via regulating iron homeostasis and endoplasmic reticulum stress against ferroptosis.
Cell Death Dis
December 2024
Department of Cardiovascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.
Aortic dissection (AD) poses a significant threat to cardiovascular health globally, yet its underlying mechanisms remain elusive. Smooth muscle cells death and phenotypic switching are critically important pathological processes in AD. Currently, no pharmacological therapies have proven effective in managing AD.
View Article and Find Full Text PDF-Associated Liver Failure: Molecular Mechanisms and Management.
Int J Mol Sci
December 2024
Department of Gastroenterology and Hepatology Campbelltown Hospital, Campbelltown, NSW 2560, Australia.
is well-established as one of the most poisonous mushrooms; toxicity from ingestion was reported as early as the first century. Although native to Europe, this ectomycorrhizal fungus has been widely spread and is responsible for liver toxicity in many parts of the world. Toxicity is characterized by delayed gastrointestinal symptoms mimicking acute gastroenteritis followed by severe hepatotoxicity and liver failure with consequent multi-organ failure.
View Article and Find Full Text PDFEffect of Silibinin on Human Pancreatic Lipase Inhibition and Gut Microbiota in Healthy Volunteers: A Randomized Controlled Trial.
Int J Mol Sci
November 2024
Unidad de Investigación de Trastornos de la Alimentación, Facultad de Enfermería, Universidad Católica de Murcia, Campus de Guadalupe, Avda. de Los Jerónimos, s/n, 30107 Murcia, Spain.
Thistle () has been traditionally employed for liver protection. However, we recently identified silibinin, the main bioactive compound of thistle extract, as an in vitro pancreatic lipase inhibitor, which suggested a potential role as an anti-obesity agent. This study aimed to assess, in vivo, the efficacy, safety, and effects of silibinin on human lipase.
View Article and Find Full Text PDFUnraveling the metabolic activities of bioactive compounds on cellular models of hepatosteatosis and adipogenesis through docking analysis with PPARs.
Sci Rep
November 2024
DISTAV, Department for the Earth, Environment and Life Sciences, University of Genova, Corso Europa 26, 16132, Genova, Italy.
Obesity is associated with fatty liver disease. Available therapies show modest efficacy, and nutraceuticals with good effectiveness and safety are largely investigated. We focused on five natural compounds, three plant phenolic compounds (carvacrol, rosmarinic acid, silybin), and two thyroid hormones (T2: 3,5-diiodo-l-thyronine; T3: 3,5,3'-triiodo-L-thyronine) as comparison, to assess their beneficial effects on two cellular models of hepatosteatosis and adipogenesis.
View Article and Find Full Text PDFHistological and Biochemical Evaluation of Silibinin in Treatment of Periodontitis Induced in Rats with Liver Cirrhosis.
J Contemp Dent Pract
July 2024
Department of Basic Dental Sciences, Oral Diagnostic Sciences Division, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia, Phone: +966 532420015, e-mail: ORCID: https://orcid.org/0000-0001-8249-5315.
Aim: This study aimed to evaluate the impact of silibinin as a therapeutic agent on ligature-induced periodontitis in rats with liver cirrhosis.
Materials And Methods: Twenty-five Wistar rats were enrolled in this study. Group A (Control) included eight rats.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!