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| http://dx.doi.org/10.1111/bcp.12342 | DOI Listing |
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Application of Fabric Phase Sorptive Extraction as a Green Method for the Analysis of 10 Anti-Diabetic Drugs in Environmental Water Samples.
Molecules
October 2024
Department of Chemistry, School of Science, University of Ioannina, 451110 Ioannina, Greece.
Due to the increased prevalence of diabetes, the consumption of anti-diabetic drugs for its treatment has likewise increased. Metformin is an anti-diabetic drug that is commonly prescribed for patients with type 2 diabetes and has been frequently detected in surface water and wastewaters, thus representing an emerging contaminant. Metformin can be prescribed in combination with other classes of anti-diabetic drugs; however, these drugs are not sufficiently investigated in environmental samples.
View Article and Find Full Text PDFPPAR-γ agonist pioglitazone and the risks of malignancy among type2 diabetes mellitus patients.
Acta Diabetol
September 2024
Nephrology Department, Linkou Medical Center, College of Medicine, Kidney Research Institute Chang Gung Memorial Hospital Chang Gung University, No.5, Fuxing Street, Guishan District, Taoyuan, 33305, Taiwan.
Aims: PPAR-gamma shows promise in inhibiting malignancy cell progression. However, pioglitazone, the sole current PPAR-gamma agonist, was reported to have risks of bladder cancer in previous clinical researches. This study is aimed to assess the influence of pioglitazone on the development of tumors.
View Article and Find Full Text PDFImpact of European Stroke Organisation secondary prevention guideline for ischaemic stroke / transient ischaemic attack.
J Stroke Cerebrovasc Dis
December 2024
School of Cardiovascular and Metabolic Health, University of Glasgow, United Kingdom. Electronic address:
Objectives: We aimed to assess secondary prevention strategies after ischaemic stroke or transient ischaemic attack (TIA).
Materials And Methods: We investigated the impact of European Stroke Organisation (ESO) Guideline recommendations for secondary prevention on recurrent events among people with non-cardioembolic ischaemic stroke or TIA. We assessed the following interventions by survival analysis or modelling impacts from clinical trial data: two blood pressure (BP) drugs compared to one drug; LDL-cholesterol target <1.
Objective: Aim: The aim of this study was to determine the effect of application of drug with circadian activity (pioglitazone) for treatment of patients with periodontist.
Patients And Methods: Materials and Methods: Group I - 18 individuals with healthy periodontium. Group II - 12 participants with stage II, grade B periodontitis treated with a standard treatment protocol.
Evaluation of Potential Furin Protease Inhibitory Properties of Pioglitazone, Rosiglitazone, and Pirfenidone: An In Silico Docking and Molecular Dynamics Simulation Approach.
Curr Issues Mol Biol
August 2024
Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Furin (Fur) is a member of the protease convertase family; its expression is crucial for cleaving and maturing many proteins. Fur also represents a therapeutic target in cancer, autoimmune diseases, and viral infections. Pioglitazone (PGZ) and rosiglitazone (RGZ) are thiazolidinediones prescribed to type 2 diabetes patients and are structurally similar to the known Fur inhibitors naphthofluorescein (NPF) and pirfenidone (PFD).
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