This article introduces a special issue that provides an overarching conceptual model for advancing the impact of science on service delivery and includes some illustrations of these concepts in action from a variety of research teams in a diversity of contexts. Themes of the special issue include balancing considerations of efficacy, effectiveness, and extensiveness--for example, ensuring that treatments are not only reliable but also robust and widely relevant. It is argued that such a balance might be achieved through an increased focus on improving coordination of system resources (e.g., clients, providers, treatments, training programs) and through dynamic and developmental designs. The special issue is intended to raise the broader question of whether our current paradigms are satisfactory in moving us toward our shared vision, or whether we could do more with what we already know.
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http://dx.doi.org/10.1080/15374416.2013.869751 | DOI Listing |
BMC Glob Public Health
January 2025
UK Health Security Agency, London, UK.
Background: The UK's National Health Service Test and Trace (NHSTT) program aimed to provide the most effective and accessible SARS-CoV-2 testing approach possible. Early user feedback indicated that there were accessibility issues associated with throat swabbing. We report the results of service evaluations performed by NHSTT to assess the effectiveness and user acceptance of swabbing approaches, as well as qualitative findings of user experiences from research reports, surveys, and incident reports.
View Article and Find Full Text PDFMol Cancer
January 2025
Department of Neurosurgery, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, 570208, China.
This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple cancer types. As small extracellular vesicles, exosomes exhibit high biocompatibility and low immunogenicity, making them ideal drug delivery vehicles capable of efficiently targeting cancer cells, minimizing off-target damage and side effects. This review aims to explore the potential of exosomes in cancer therapy, with a focus on applications in chemotherapy, gene therapy, and immunomodulation.
View Article and Find Full Text PDFJ Transl Med
January 2025
Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Background: Multiple myeloma (MM) is an incurable plasma cell malignancy with increasing global incidence. Chimeric antigen receptor (CAR) T-cell therapy targeting BCMA has shown efficacy in relapsed or refractory MM, but it faces resistance due to antigen loss and the tumor microenvironment. Bispecific T-cell engaging (BITE) antibodies also encounter clinical challenges, including short half-lives requiring continuous infusion and potential toxicities.
View Article and Find Full Text PDFBMC Med Educ
January 2025
Nursing and Midwifery Care Research Center, Department Of Community Health and Geriatric Nursing, Iran University of Medical Sciences, Tehran, Iran.
Background And Purpose: The purpose of reflection in the learning process is to create meaningful and deep learning. Considering the importance of emphasizing active and student-centered methods in learning and the necessity of learners' participation in the education process, the present study was conducted to investigate the effect of flipped classroom teaching method on the amount of reflection ability in nursing students and the course of professional ethics.
Study Method: The current study is a quasi-experimental study using Solomon's four-group method.
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