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Alcohol and emotion: Analyzing convergence between facially expressed and self-reported indices of emotion under alcohol intoxication.
Psychol Addict Behav
January 2025
Department of Psychology, University of Illinois, Urbana-Champaign.
Objective: Emotion measurement is central to capturing acute alcohol reinforcement and so to informing models of alcohol use disorder etiology. Yet our understanding of how alcohol impacts emotion as assessed across diverse response modalities remains incomplete. The present study leverages a social alcohol-administration paradigm to assess drinking-related emotions, aiming to elucidate impacts of intoxication on self-reported versus behaviorally expressed emotion.
View Article and Find Full Text PDFImmune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes.
Cancer Res
December 2024
Rutgers, The State University of New Jersey, New Brunswick, NJ, United States.
Mutations in the exonuclease domains of the replicative nuclear DNA polymerases POLD1 and POLE are associated with increased cancer incidence, elevated tumor mutation burden (TMB), and enhanced response to immune checkpoint blockade (ICB). Although ICB is approved for treatment of several cancers, not all tumors with elevated TMB respond, highlighting the need for a better understanding of how TMB affects tumor biology and subsequently immunotherapy response. To address this, we generated mice with germline and conditional mutations in the exonuclease domains of Pold1 and Pole.
View Article and Find Full Text PDFMajor Depressive Disorder and Driving Behavior Among Older Adults.
JAMA Netw Open
December 2024
Department of Psychiatry, Washington University in St Louis, St Louis, Missouri.
Importance: Depression and antidepressant use are independently associated with crash risk among older drivers. However, it is unclear what factors impact daily driving that increase safety risk for drivers with depression.
Objective: To examine differences in naturalistic driving behavior and safety between older adults with and without major depressive disorder (MDD).
Background: The choroid plexus (ChP) plays a vital role in CSF production and waste clearance. While existing imaging studies have established connections between ChP volume changes and age-related neurodegenerative diseases, a comprehensive investigation into the microstructural and vascular changes associated with aging remains insufficient. This study aims to explore ChP changes in normal aging using diffusion and perfusion MRI in the HCP-Aging dataset to enhance our understanding of age-related microstructural and vascular changes in the ChP.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Bernard and Irene Schwartz Center for Biomedical Imaging, New York University Grossman School of Medicine, New York, NY, USA.
Background: Amyloid related imaging abnormalities (ARIA), a group of neuropathological features seen in anti-amyloid immunotherapy patients, arises partly from CAA (Aβ buildup in blood vessels). Squirrel monkeys (SQMs), developing prominent age-related CAA exceeding brain Aβ, offer a unique NHP model for ARIA study. Evaluating edema-related neurobiological defects (ARIA-E) involves preferential use of T-weighted (T-w) and flow-attenuated inversion recovery (FLAIR) MRI while T*-weighted (T*-w) MRI is better suited for investigating iron-related pathology like microbleeds, hemorrhaging, and iron-homing in plaques.
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