AI Article Synopsis

  • The study investigates the link between HPV infection and parotid gland tumors by analyzing tissue samples from 59 tumor cases and comparing them with 20 normal oral mucosa samples.
  • The research found a significant HPV-positive rate of 57.6% in parotid gland tumor samples, with benign tumors showing a slightly higher rate (59.6%) than malignant ones (42.9%).
  • High-risk HPV types were predominantly present in the tumors, with HPV 16, 18, and 52 being the most common, suggesting a strong correlation between HPV infection and the development of parotid gland tumors.

Article Abstract

Human papillomavirus (HPV) infection has been shown to be associated with human tumorigenesis. The aim of the present study was to demonstrate the association between HPV infection and parotid gland tumors. Paraffin-embedded tissue sections from 59 cases of parotid gland tumors and 20 normal oral mucosa were subjected to DNA extraction and flow-through hybridization and gene chip technology to detect infection of 37 HPV types. The HPV-positive rate was 57.6% in parotid gland tumor paraffin-embedded tissue specimens, whereas, the normal control group was negative for HPV. The HPV-positive rate was 59.6% in parotid gland benign tumor tissues and 42.9% in parotid malignant tissues. HPV infection in parotid gland tumors was dominated by the high-risk subtypes (80.7%), which mainly consisted of HPV 16, 18 and 52 (61.4%). In addition, parotid gland tumor tissues were found to be infected by multiple or single types of HPV, but were predominantly infected by mixed HPV types. In this study, we found that the occurrence of parotid gland tumor is correlated with HPV infection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919866PMC
http://dx.doi.org/10.3892/ol.2013.1770DOI Listing

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